Abstract
A chemical investigation of an ethyl acetate extract of the Red Sea soft coral
Sarcophyton glaucum has led to the isolation of two peroxide diterpenes, 11(S)
hydroperoxylsarcoph-12(20)-ene (1), and 12(S)-hydroperoxylsarcoph-10-ene (2), as well
as 8-epi-sarcophinone (3). In addition to these three new compounds, two known structures
were identified including: ent-sarcophine (4) and sarcophine (5). Structures were elucidated
by spectroscopic analysis, with the relative configuration of 1 and 2 confirmed by X-ray
diffraction. Isolated compounds were found to be inhibitors of cytochrome P450 1A activity
as well as inducers of glutathione S-transferases (GST), quinone reductase (QR), and
epoxide hydrolase (mEH) establishing chemo-preventive and tumor anti-initiating activity
for these characterized metabolites.
Original language | English |
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Pages (from-to) | 209-222 |
Journal | Marine Drugs |
State | Published - Jan 18 2012 |