TY - GEN
T1 - Bingham fluid-assisted fabrication of 3D vascular-like constructs of interpenetrating network hydrogel
AU - Krishnamoorthy, Srikumar
AU - Song, Hongtao
AU - Zhang, Mengyun
AU - Xu, Changxue
N1 - Publisher Copyright:
Copyright © 2017 ASME.
PY - 2017
Y1 - 2017
N2 - Organ printing, which utilizes advanced manufacturing technologies to fabricate three-dimensional (3D) functional organs based on layer-by-layer mechanism, is emerging as a promising solution to solve the organ donor shortage problem affecting all over the world. One of the biggest challenges for fabrication of functional and effective thick tissues/organs is the engineering of vascular networks. This paper introduces a Bingham fluid (Carbopol gel) to assist fabrication of 3D vascular-like constructs of interpenetrating network (IPN) hydrogels. Carbopol gel as a Bingham fluid exhibits a characteristic yield stress behavior. As the nozzle moves inside Carbopol, the shear stress is larger than the yield stress and the Carbopol gel behaves like a viscous fluid with a specific viscosity. After the nozzle moves away, the shear stress decreases below the yield stress and the Carbopol gel rapidly solidifies behaving like a solid. This unique rheological property is utilized to support and maintain the shape of the fabricated 3D structures, although the fluid printed is not crosslinked. Finally, the fabricated structures are subject to a two-step gelation process to successfully form 3D vascular-like constructs of IPN hydrogels. This novel approach enables effective and efficient fabrication of complex vascular network of IPN hydrogels.
AB - Organ printing, which utilizes advanced manufacturing technologies to fabricate three-dimensional (3D) functional organs based on layer-by-layer mechanism, is emerging as a promising solution to solve the organ donor shortage problem affecting all over the world. One of the biggest challenges for fabrication of functional and effective thick tissues/organs is the engineering of vascular networks. This paper introduces a Bingham fluid (Carbopol gel) to assist fabrication of 3D vascular-like constructs of interpenetrating network (IPN) hydrogels. Carbopol gel as a Bingham fluid exhibits a characteristic yield stress behavior. As the nozzle moves inside Carbopol, the shear stress is larger than the yield stress and the Carbopol gel behaves like a viscous fluid with a specific viscosity. After the nozzle moves away, the shear stress decreases below the yield stress and the Carbopol gel rapidly solidifies behaving like a solid. This unique rheological property is utilized to support and maintain the shape of the fabricated 3D structures, although the fluid printed is not crosslinked. Finally, the fabricated structures are subject to a two-step gelation process to successfully form 3D vascular-like constructs of IPN hydrogels. This novel approach enables effective and efficient fabrication of complex vascular network of IPN hydrogels.
UR - http://www.scopus.com/inward/record.url?scp=85027837115&partnerID=8YFLogxK
U2 - 10.1115/MSEC20172898
DO - 10.1115/MSEC20172898
M3 - Conference contribution
AN - SCOPUS:85027837115
T3 - ASME 2017 12th International Manufacturing Science and Engineering Conference, MSEC 2017 collocated with the JSME/ASME 2017 6th International Conference on Materials and Processing
BT - Bio and Sustainable Manufacturing
PB - American Society of Mechanical Engineers
T2 - ASME 2017 12th International Manufacturing Science and Engineering Conference, MSEC 2017 collocated with the JSME/ASME 2017 6th International Conference on Materials and Processing
Y2 - 4 June 2017 through 8 June 2017
ER -