Bingham fluid-assisted fabrication of 3D vascular-like constructs of interpenetrating network hydrogel

Srikumar Krishnamoorthy, Hongtao Song, Mengyun Zhang, Changxue Xu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Organ printing, which utilizes advanced manufacturing technologies to fabricate three-dimensional (3D) functional organs based on layer-by-layer mechanism, is emerging as a promising solution to solve the organ donor shortage problem affecting all over the world. One of the biggest challenges for fabrication of functional and effective thick tissues/organs is the engineering of vascular networks. This paper introduces a Bingham fluid (Carbopol gel) to assist fabrication of 3D vascular-like constructs of interpenetrating network (IPN) hydrogels. Carbopol gel as a Bingham fluid exhibits a characteristic yield stress behavior. As the nozzle moves inside Carbopol, the shear stress is larger than the yield stress and the Carbopol gel behaves like a viscous fluid with a specific viscosity. After the nozzle moves away, the shear stress decreases below the yield stress and the Carbopol gel rapidly solidifies behaving like a solid. This unique rheological property is utilized to support and maintain the shape of the fabricated 3D structures, although the fluid printed is not crosslinked. Finally, the fabricated structures are subject to a two-step gelation process to successfully form 3D vascular-like constructs of IPN hydrogels. This novel approach enables effective and efficient fabrication of complex vascular network of IPN hydrogels.

Original languageEnglish
Title of host publicationBio and Sustainable Manufacturing
PublisherAmerican Society of Mechanical Engineers
ISBN (Electronic)9780791850756
DOIs
StatePublished - Jan 1 2017
EventASME 2017 12th International Manufacturing Science and Engineering Conference, MSEC 2017 collocated with the JSME/ASME 2017 6th International Conference on Materials and Processing - Los Angeles, United States
Duration: Jun 4 2017Jun 8 2017

Publication series

NameASME 2017 12th International Manufacturing Science and Engineering Conference, MSEC 2017 collocated with the JSME/ASME 2017 6th International Conference on Materials and Processing
Volume4

Conference

ConferenceASME 2017 12th International Manufacturing Science and Engineering Conference, MSEC 2017 collocated with the JSME/ASME 2017 6th International Conference on Materials and Processing
CountryUnited States
CityLos Angeles
Period06/4/1706/8/17

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Krishnamoorthy, S., Song, H., Zhang, M., & Xu, C. (2017). Bingham fluid-assisted fabrication of 3D vascular-like constructs of interpenetrating network hydrogel. In Bio and Sustainable Manufacturing (ASME 2017 12th International Manufacturing Science and Engineering Conference, MSEC 2017 collocated with the JSME/ASME 2017 6th International Conference on Materials and Processing; Vol. 4). American Society of Mechanical Engineers. https://doi.org/10.1115/MSEC20172898