ATP synthesis driven by proton transport in F1F0-ATP synthase

Joachim Weber, Alan E. Senior

Research output: Contribution to journalShort surveypeer-review

234 Scopus citations


Topical questions in ATP synthase research are: (1) how do protons cause subunit rotation and how does rotation generate ATP synthesis from ADP+Pi? (2) How does hydrolysis of ATP generate subunit rotation and how does rotation bring about uphill transport of protons? The finding that ATP synthase is not just an enzyme but rather a unique nanomotor is attracting a diverse group of researchers keen to find answers. Here we review the most recent work on rapidly developing areas within the field and present proposals for enzymatic and mechanoenzymatic mechanisms.

Original languageEnglish
Pages (from-to)61-70
Number of pages10
JournalFEBS Letters
Issue number1
StatePublished - Jun 12 2003


  • ATP hydrolysis
  • ATP synthase
  • ATP synthesis
  • Molecular motor
  • Proton transport
  • Subunit rotation


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