ATP synthase - the structure of the stator stalk

Joachim Weber

doi:10.1016/j.tibs.2006.12.006

ATP synthase - the structure of the stator stalk

Joachim Weber

Chemistry and Biochemistry

Research output: Contribution to journal › Short survey › peer-review

34 Scopus citations

Abstract

ATP synthase synthesizes ATP from ADP and inorganic phosphate using a unique rotary mechanism whereby two subcomplexes move relative to each other, powered by a proton or sodium gradient. The non-rotating parts of the machinery are held together by the 'stator stalk'. The recent resolution of the structure of a major portion of the stator stalk of mitochondrial ATP synthase represents an important step towards a structural model for the ATP synthase holoenzyme.

Original language	English
Pages (from-to)	53-56
Number of pages	4
Journal	Trends in Biochemical Sciences
Volume	32
Issue number	2
DOIs	https://doi.org/10.1016/j.tibs.2006.12.006
State	Published - Feb 2007

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10.1016/j.tibs.2006.12.006

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abstract = "ATP synthase synthesizes ATP from ADP and inorganic phosphate using a unique rotary mechanism whereby two subcomplexes move relative to each other, powered by a proton or sodium gradient. The non-rotating parts of the machinery are held together by the 'stator stalk'. The recent resolution of the structure of a major portion of the stator stalk of mitochondrial ATP synthase represents an important step towards a structural model for the ATP synthase holoenzyme.",

author = "Joachim Weber",

note = "Funding Information: Work in the author's laboratory is supported by the NIH (GM076214).",

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AB - ATP synthase synthesizes ATP from ADP and inorganic phosphate using a unique rotary mechanism whereby two subcomplexes move relative to each other, powered by a proton or sodium gradient. The non-rotating parts of the machinery are held together by the 'stator stalk'. The recent resolution of the structure of a major portion of the stator stalk of mitochondrial ATP synthase represents an important step towards a structural model for the ATP synthase holoenzyme.

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ATP synthase - the structure of the stator stalk

Abstract

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