Abstract
Efficient asymmetric Mannich addition reactions between α,β-unsaturated ketone derived enolates and N-phosphonyl imines were reported. These reactions could proceed smoothly for a variety of imine substrates with good (up to 96%) chemical yields and excellent diastereoselectivities (up to 98:2 dr). The method reported in this work provides an easy access to chiral β′-amino-α,β-enones.
Original language | English |
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Pages (from-to) | 2476-2479 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 55 |
Issue number | 15 |
DOIs | |
State | Published - Apr 9 2014 |
Keywords
- Asymmetric Mannich reaction
- Diastereoselectivity
- N-Phosphonyl imine
- α,β-Unsaturated ketone
- β′-Amino-α,β-enones