Asymmetric synthesis of α-alkenyl homoallylic primary amines via 1,2-addition of Grignard reagent to α,β-unsaturated phosphonyl imines

Yiwen Xiong, Haibo Mei, Chen Xie, Jianlin Han, Guigen Li, Yi Pan

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A series of chiral N-phosphonyl protected α-alkenyl homoallylic primary amines were synthesized by asymmetric addition of allylmagnesium bromide to chiral α,β-unsaturated imines. Only the 1,2-adduct was obtained for all the imines with good yields and excellent diastereoselectivities. The chiral auxiliary could be easily removed under simple conditions, giving free multiple functionalized primary amines.

Original languageEnglish
Pages (from-to)15820-15826
Number of pages7
JournalRSC Advances
Volume3
Issue number36
DOIs
StatePublished - Sep 28 2013

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