Abstract
A series of chiral N-phosphonyl protected α-alkenyl homoallylic primary amines were synthesized by asymmetric addition of allylmagnesium bromide to chiral α,β-unsaturated imines. Only the 1,2-adduct was obtained for all the imines with good yields and excellent diastereoselectivities. The chiral auxiliary could be easily removed under simple conditions, giving free multiple functionalized primary amines.
Original language | English |
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Pages (from-to) | 15820-15826 |
Number of pages | 7 |
Journal | RSC Advances |
Volume | 3 |
Issue number | 36 |
DOIs | |
State | Published - Sep 28 2013 |