Abstract
An asymmetric organocatalytic tandem reaction comprising cyclization/transfer hydrogenation has been established in a compatible and synergistic way, leading to the step-economical synthesis of enantioenriched tetrahydroquinoxalines and dihydroquinoxalinones from readily accessible materials in excellent enantioselectivity of up to >99% ee. This protocol of a one-operation tandem reaction combines the merits of both tandem reactions and asymmetric organocatalysis, providing an efficient strategy for concisely and enantioselectively synthesizing nitrogen heterocycles with biological relevance.
Original language | English |
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Pages (from-to) | 3715-3726 |
Number of pages | 12 |
Journal | Advanced Synthesis and Catalysis |
Volume | 355 |
Issue number | 18 |
DOIs | |
State | Published - Dec 16 2013 |
Keywords
- asymmetric catalysis
- enantioselectivity
- organic catalysis
- tandem reaction
- transfer hydrogenation