Asymmetric halo aldol reaction (AHA)

Guigen Li, Xin Xu, Dianjun Chen, Cody Timmons, Michael D. Carducci, Allan D. Headley

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

(Matrix presented) The asymmetric halo aldol reaction (AHA) using Evans oxazolidinones as chiral auxiliaries has been established for tandem I-C/C-C bond formations. The new asymmetric reaction provides a practical approach to a variety of halo aldols of a non-Evans type that cannot be easily synthesized by other methods. Excellent diastereoselectivity (>95%) and yields (80-93%) have been obtained for eight examples.

Original languageEnglish
Pages (from-to)329-331
Number of pages3
JournalOrganic Letters
Volume5
Issue number3
DOIs
StatePublished - Feb 6 2003

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    Li, G., Xu, X., Chen, D., Timmons, C., Carducci, M. D., & Headley, A. D. (2003). Asymmetric halo aldol reaction (AHA). Organic Letters, 5(3), 329-331. https://doi.org/10.1021/ol027344+