Asymmetric conduction in biological nanopores created by high-intensity, nanosecond pulsing: Inference on internal charge lining the membrane based on a model study

R. P. Joshi, H. Qiu

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Nanosecond, high-intensity electric pulses have been reported to open rectifying pores in biological cell membranes. The present goal is to qualitatively understand and analyze the experimental current-voltage (I-V) data. Here, nanopore transport is probed using a numerical method and on the basis of an analytical model. Our results show that geometric asymmetry in the nanopore would not yield asymmetry in the I-V characteristics. However, positive surface charge lining the pore could produce characteristics that compare well with data from patch-clamp measurements, and a value of ∼0.02C/m2 is predicted from the numerical calculations.

Original languageEnglish
Article number094701
JournalJournal of Applied Physics
Volume118
Issue number9
DOIs
StatePublished - Sep 7 2015

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