TY - JOUR
T1 - Asymmetric conduction in biological nanopores created by high-intensity, nanosecond pulsing
T2 - Inference on internal charge lining the membrane based on a model study
AU - Joshi, R. P.
AU - Qiu, H.
N1 - Publisher Copyright:
© 2015 AIP Publishing LLC.
PY - 2015/9/7
Y1 - 2015/9/7
N2 - Nanosecond, high-intensity electric pulses have been reported to open rectifying pores in biological cell membranes. The present goal is to qualitatively understand and analyze the experimental current-voltage (I-V) data. Here, nanopore transport is probed using a numerical method and on the basis of an analytical model. Our results show that geometric asymmetry in the nanopore would not yield asymmetry in the I-V characteristics. However, positive surface charge lining the pore could produce characteristics that compare well with data from patch-clamp measurements, and a value of ∼0.02C/m2 is predicted from the numerical calculations.
AB - Nanosecond, high-intensity electric pulses have been reported to open rectifying pores in biological cell membranes. The present goal is to qualitatively understand and analyze the experimental current-voltage (I-V) data. Here, nanopore transport is probed using a numerical method and on the basis of an analytical model. Our results show that geometric asymmetry in the nanopore would not yield asymmetry in the I-V characteristics. However, positive surface charge lining the pore could produce characteristics that compare well with data from patch-clamp measurements, and a value of ∼0.02C/m2 is predicted from the numerical calculations.
UR - http://www.scopus.com/inward/record.url?scp=84941126570&partnerID=8YFLogxK
U2 - 10.1063/1.4929808
DO - 10.1063/1.4929808
M3 - Article
AN - SCOPUS:84941126570
VL - 118
JO - Journal of Applied Physics
JF - Journal of Applied Physics
SN - 0021-8979
IS - 9
M1 - 094701
ER -