Asymmetric catalytic Strecker reaction of N-phosphonyl imines with Et 2AlCN using amino alcohols and BINOLs as catalysts

Parminder Kaur, Suresh Pindi, Walter Wever, Trideep Rajale, Guigen Li

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

The asymmetric catalytic Strecker reaction of achiral N-phosphonyl imines with Et2AlCN has been established. Both free amino alcohols and BINOLs have been proven to be effective catalysts to afford excellent enantioselectivities and yields. The N-phosphonyl group can be readily cleaved under mild conditions and enable purification of crude products by simple washing with hexane. The cleaved N,N-dialkyl diamine auxiliary can be recovered quantitatively via n-BuOH extraction. The scope for both N-phosphonyl imines and catalysts was vastly studied for this new catalytic system.

Original languageEnglish
Pages (from-to)4330-4332
Number of pages3
JournalChemical Communications
Volume46
Issue number24
DOIs
StatePublished - 2010

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