Abstract
An efficient catalytic system has been established for the asymmetric
boron conjugate addition of B(2)pin(2) onto alpha-functionalized
(involving C, N, O, and Cl) a alpha,beta-unsaturated carbonyls under
mild, neutral conditions involving Cu[(S)-(R)-ppfa]Cl, AgNTf2, and
alcohols. The dual additives of AgNTf2 and alcohols were found to play
crucial roles for achieving high catalytic activity and enantio- and
diastereoselectivity (up to 98% ee and 70:1 dr).
Original language | English |
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Pages (from-to) | 3926-3929 |
Journal | Organic Letters |
State | Published - Aug 2016 |