Asymmetric Catalytic Enantio- and Diastereoselective Boron Conjugate Addition Reactions of alpha-Functionalized alpha,beta-Unsaturated Carbonyl Substrates

Jian-Bo Xie, Siqi Lin, Shuo Qiao, Guigen Li

Research output: Contribution to journalArticle

Abstract

An efficient catalytic system has been established for the asymmetric boron conjugate addition of B(2)pin(2) onto alpha-functionalized (involving C, N, O, and Cl) a alpha,beta-unsaturated carbonyls under mild, neutral conditions involving Cu[(S)-(R)-ppfa]Cl, AgNTf2, and alcohols. The dual additives of AgNTf2 and alcohols were found to play crucial roles for achieving high catalytic activity and enantio- and diastereoselectivity (up to 98% ee and 70:1 dr).
Original languageEnglish
Pages (from-to)3926-3929
JournalOrganic Letters
StatePublished - Aug 2016

Fingerprint Dive into the research topics of 'Asymmetric Catalytic Enantio- and Diastereoselective Boron Conjugate Addition Reactions of alpha-Functionalized alpha,beta-Unsaturated Carbonyl Substrates'. Together they form a unique fingerprint.

Cite this