Abstract
An efficient catalytic system has been established for the asymmetric boron conjugate addition of B2pin2 onto α-functionalized (involving C, N, O, and Cl) α,β-unsaturated carbonyls under mild, neutral conditions involving Cu[(S)-(R)-ppfa]Cl, AgNTf2, and alcohols. The dual additives of AgNTf2 and alcohols were found to play crucial roles for achieving high catalytic activity and enantio- and diastereoselectivity (up to 98% ee and 70:1 dr).
| Original language | English |
|---|---|
| Pages (from-to) | 3926-3929 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 18 |
| Issue number | 15 |
| DOIs | |
| State | Published - Aug 5 2016 |
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Xie, J. B., Lin, S., Qiao, S., & Li, G. (2016). Asymmetric Catalytic Enantio- and Diastereoselective Boron Conjugate Addition Reactions of α-Functionalized α,β-Unsaturated Carbonyl Substrates. Organic Letters, 18(15), 3926-3929. https://doi.org/10.1021/acs.orglett.6b01998