Asymmetric Catalytic Enantio- and Diastereoselective Boron Conjugate Addition Reactions of α-Functionalized α,β-Unsaturated Carbonyl Substrates

Jian Bo Xie, Siqi Lin, Shuo Qiao, Guigen Li

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

An efficient catalytic system has been established for the asymmetric boron conjugate addition of B2pin2 onto α-functionalized (involving C, N, O, and Cl) α,β-unsaturated carbonyls under mild, neutral conditions involving Cu[(S)-(R)-ppfa]Cl, AgNTf2, and alcohols. The dual additives of AgNTf2 and alcohols were found to play crucial roles for achieving high catalytic activity and enantio- and diastereoselectivity (up to 98% ee and 70:1 dr).

Original languageEnglish
Pages (from-to)3926-3929
Number of pages4
JournalOrganic Letters
Volume18
Issue number15
DOIs
StatePublished - Aug 5 2016

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