Asymmetric boron conjugate addition to α,β-unsaturated carbonyl compounds catalyzed by CuOTf/Josiphos under non-alkaline conditions

Jian Bo Xie, Siqi Lin, Jian Luo, Jianbin Wu, Timothy R. Winn, Guigen Li

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The asymmetric boron conjugate addition onto α,β-unsaturated ketones and esters has been developed by using the CuOTf/Josiphos complex as the catalyst under non-alkaline conditions. It was found that the addition of MeOH into the reaction system is crucial to the catalytic reactivity. Good to excellent enantioselectivity (up to 96% ee) and yields (up to 98%) have been achieved for 15 examples.

Original languageEnglish
Pages (from-to)42-46
Number of pages5
JournalOrganic Chemistry Frontiers
Volume2
Issue number1
DOIs
StatePublished - Jan 2015

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