Association between exercise hemodynamics and changes in local vaascular function following acute exercise

Joaquin Gonzales, Benjamin C. Thompson, John R. Thistlethwaite, Barry W. Scheuermann

Research output: Contribution to journalArticlepeer-review

Abstract

Skeletal muscle contractions are associated with physical stimuli that act upon muscle vasculature including increased shear stress and blood pressure. It is unclear if acute dynamic exercise alters local vascular function. The purpose of this study was to examine the role of exercise hemodynamics on the effects of acute exercise on vascular function, as evaluated by brachial artery flow-mediated dilation (FMD). Healthy individuals (N=14, 18-34 y) performed 30 min of handgrip exercise at fast and slow contractions. Blood pressure (BP) during exercise was measured using a Vasotrac system, while shear rate during exercise and FMD at rest and after 30 min of recovery from exercise were measured in the brachial artery of the active arm using Doppler ultrasound. Estimated contractile work was correlated with BP (r=0.61, P<0.01) and retrograde shear rate (r=-0.78, P<0.01). As a result, BP was higher (P<0.05) and oscillatory shear index was lower (P<0.05) during slow as compared to fas
Original languageEnglish
Pages (from-to)137-144
JournalApplied Physiology, Nutrition, and Metabolism
DOIs
StatePublished - Feb 15 2011

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