Use of coproducts such as corn and sorghum distillers grain (DG) and corn gluten feed (CGF) in beef cattle finishing diets has increased significantly in recent years, but research to evaluate the efficacy of traditional feeding practices and feed additives when coproducts are fed has not kept pace. Grain processing methods that increase starch availability seem equally effective in traditional diets and diets with wet CGF; however, in wet DG diets, some studies have shown decreased efficacy of grain processing, whereas others have shown no evidence of an interaction. Limited data are available on the physical and nutritional value of the fiber in wet DG and CGF; however, CGF at concentrations >/=25% of the dietary DM seems to have some degree of "roughage value," whereas fiber in wet DG seems to have less potential to replace traditional roughage sources. There is little evidence that efficacy of ionophores and antibiotics is changed with diets based on wet CGF or that they interact when wet DG is added to finishing diets. In vitro data from our laboratory suggest no loss of monensin efficacy in substrates with 15% (DM basis) corn DG in terms of changes in VFA and gas production. Moreover, efficacy of ionophores was not affected in our data by diet substrates with increasing concentrations of S, and in vitro H(2)S production in substrates containing wet DG seems predictable from substrate S concentrations. Nonetheless, limited in vivo data indicate decreased ruminal acetate-to-propionate ratios in diets with increased wet DG, which may minimize the potential for ionophores to alter propionate. Likewise, in vivo results indicate that feeding wet DG may decrease ruminal pH; thus, to maximize DMI and minimize digestive upsets, optimal concentrations of roughage need to be evaluated in diets containing wet DG. Research is needed on other potential technology interactions with coproducts of biofuel production such as glycerol and condensed distillers solubles. The effects of yeast products and live microbial cultures in diets with coproduct feeds have generally not been determined. Because of the elevated fiber concentrations in CGF and DG, effects of exogenous enzyme preparations on ruminal fermentation and fiber digestion of diets containing these coproducts should be evaluated.