Applications of nanomaterials for activation and suppression of immune responses

Akhilesh Kumar Shakya, Kutty Selva Nandakumar

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Evaluation of immuno-modulating properties of nanomaterials is important to develop new potential therapeutics for inflammatory diseases and cancer. Activation and suppressive effects of nanomaterials on immune responses occur through various interactions with different host proteins. They can also be engineered as carriers and/or adjuvants for different proteins or antigens. Particles, emulsions, and tubes/rods are the major formats of nanomaterials currently used in biomedical applications. Sometimes, nanomaterials induce side effects like undesired immunosuppression and toxicities, which are major concerns at present in designing optimal nanotherapeutics. This chapter summarizes different types of nanomaterials and their effect on immune responses.

Original languageEnglish
Title of host publicationHandbook of Research on Diverse Applications of Nanotechnology in Biomedicine, Chemistry, and Engineering
PublisherIGI-Global
Pages205-220
Number of pages16
ISBN (Electronic)9781466663640
ISBN (Print)1466663634, 9781466663633
DOIs
StatePublished - Aug 31 2014

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    Shakya, A. K., & Nandakumar, K. S. (2014). Applications of nanomaterials for activation and suppression of immune responses. In Handbook of Research on Diverse Applications of Nanotechnology in Biomedicine, Chemistry, and Engineering (pp. 205-220). IGI-Global. https://doi.org/10.4018/978-1-4666-6363-3.ch011