TY - JOUR
T1 - Applications and safety considerations of Lactobacillus salivarius as a probiotic in animal and human health
AU - Chaves, B. D.
AU - Brashears, M. M.
AU - Nightingale, K. K.
N1 - Publisher Copyright:
© 2017 The Society for Applied Microbiology
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2017/7
Y1 - 2017/7
N2 - The goals of this review are to summarize the current knowledge on the application of Lactobacillus salivarius as a probiotic in animals and humans, and to address safety concerns with its use on live hosts. Overall, several strains of L. salivarius are well established probiotics with multiple applications in animal health, particularly to reduce colonization by gastrointestinal pathogens, and to a lesser extent, as a production and quality aid. In humans, L. salivarius has been used to prevent and treat a variety of chronic diseases, including asthma, cancer, atopic dermatitis and halitosis, and to a much limited extent, to prevent or treat infections. Based on the results from primary research evidence, it seems that L. salivarius does not pose a health risk to animals or humans in the doses currently used for a variety of applications; however, there is a systematic lack of studies assuring the safety of many of the strains intended for clinical use. This review provides researchers in the field with up-to-date information regarding applications and safety of L. salivarius. Furthermore, it helps researchers identify knowledge gaps and potential opportunities for microbiological and clinical research.
AB - The goals of this review are to summarize the current knowledge on the application of Lactobacillus salivarius as a probiotic in animals and humans, and to address safety concerns with its use on live hosts. Overall, several strains of L. salivarius are well established probiotics with multiple applications in animal health, particularly to reduce colonization by gastrointestinal pathogens, and to a lesser extent, as a production and quality aid. In humans, L. salivarius has been used to prevent and treat a variety of chronic diseases, including asthma, cancer, atopic dermatitis and halitosis, and to a much limited extent, to prevent or treat infections. Based on the results from primary research evidence, it seems that L. salivarius does not pose a health risk to animals or humans in the doses currently used for a variety of applications; however, there is a systematic lack of studies assuring the safety of many of the strains intended for clinical use. This review provides researchers in the field with up-to-date information regarding applications and safety of L. salivarius. Furthermore, it helps researchers identify knowledge gaps and potential opportunities for microbiological and clinical research.
KW - Lactobacillus salivarius
KW - animal health
KW - human health
KW - probiotics
KW - safety assessment
UR - http://www.scopus.com/inward/record.url?scp=85018784213&partnerID=8YFLogxK
U2 - 10.1111/jam.13438
DO - 10.1111/jam.13438
M3 - Review article
C2 - 28256040
AN - SCOPUS:85018784213
VL - 123
SP - 18
EP - 28
JO - Journal of Applied Microbiology
JF - Journal of Applied Microbiology
SN - 1364-5072
IS - 1
ER -