Application of Hantzsch Ester and Meyer Nitrile in Radical Alkynylation Reactions

Xu Liu; Ruoyu Liu; Jie Dai; Xu Cheng; Guigen Li

doi:10.1021/acs.orglett.8b03050

Application of Hantzsch Ester and Meyer Nitrile in Radical Alkynylation Reactions

Xu Liu, Ruoyu Liu, Jie Dai, Xu Cheng, Guigen Li

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The first example of constructing a C _sp3 -C _sp bond with substituted Hantzsch ester and Meyer nitrile is reported. When benziodoxole-activated alkyne was applied as the alkynyl donor, products containing C _sp3 -C _sp bonds involving primary, secondary, and tertiary carbon centers were achieved in up to 97% yields. K ₂ S ₂ O ₈ was the optimum radical initiator in this reaction.

Original language	English
Pages (from-to)	6906-6909
Number of pages	4
Journal	Organic Letters
Volume	20
Issue number	21
DOIs	https://doi.org/10.1021/acs.orglett.8b03050
State	Published - Nov 2 2018

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title = "Application of Hantzsch Ester and Meyer Nitrile in Radical Alkynylation Reactions",

abstract = " The first example of constructing a C sp3 -C sp bond with substituted Hantzsch ester and Meyer nitrile is reported. When benziodoxole-activated alkyne was applied as the alkynyl donor, products containing C sp3 -C sp bonds involving primary, secondary, and tertiary carbon centers were achieved in up to 97% yields. K 2 S 2 O 8 was the optimum radical initiator in this reaction. ",

author = "Xu Liu and Ruoyu Liu and Jie Dai and Xu Cheng and Guigen Li",

year = "2018",

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doi = "10.1021/acs.orglett.8b03050",

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AU - Liu, Xu

AU - Liu, Ruoyu

AU - Dai, Jie

AU - Cheng, Xu

AU - Li, Guigen

PY - 2018/11/2

Y1 - 2018/11/2

N2 - The first example of constructing a C sp3 -C sp bond with substituted Hantzsch ester and Meyer nitrile is reported. When benziodoxole-activated alkyne was applied as the alkynyl donor, products containing C sp3 -C sp bonds involving primary, secondary, and tertiary carbon centers were achieved in up to 97% yields. K 2 S 2 O 8 was the optimum radical initiator in this reaction.

AB - The first example of constructing a C sp3 -C sp bond with substituted Hantzsch ester and Meyer nitrile is reported. When benziodoxole-activated alkyne was applied as the alkynyl donor, products containing C sp3 -C sp bonds involving primary, secondary, and tertiary carbon centers were achieved in up to 97% yields. K 2 S 2 O 8 was the optimum radical initiator in this reaction.

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DO - 10.1021/acs.orglett.8b03050

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