Application of Hantzsch Ester and Meyer Nitrile in Radical Alkynylation Reactions

Xu Liu, Ruoyu Liu, Jie Dai, Xu Cheng, Guigen Li

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The first example of constructing a C sp3 -C sp bond with substituted Hantzsch ester and Meyer nitrile is reported. When benziodoxole-activated alkyne was applied as the alkynyl donor, products containing C sp3 -C sp bonds involving primary, secondary, and tertiary carbon centers were achieved in up to 97% yields. K 2 S 2 O 8 was the optimum radical initiator in this reaction.

Original languageEnglish
Pages (from-to)6906-6909
Number of pages4
JournalOrganic Letters
Volume20
Issue number21
DOIs
StatePublished - Nov 2 2018

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