Antisense transcription associated with microRNA target mRNAs

Christopher Rock, Qing-Jun Luo, Fangqian Ou-Yang

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Here we review recent progress on understanding the biological significance and pervasiveness of transitivity (RNA silencing phenomena) associated with miRNAs in plants and comparisons with parallels in animals. The importance of RNA surveillance and splicing machineries in miRNA biogenesis as it relates to substrate availability for RNA interference is discussed. We summarize a meta-analysis of deep sequencing datasets which reveals a novel case base substituion of miRNAs in Arabidopsis that results in perfect matches to their targets that spawn siRNAs. We discuss current models for RNA interference triggers by miRNAs and the potential involvement of RNA editases, Dicers, and Argonautes. We conclude with some speculation on the role of transposon silencing in rice contributing to evolution of a class of miRNAs with predicted targets in 3’-UTRs, which may serve to assemble adaptive stress response networks and reveal a con-served mechanistic link between animal and plant miRNA fun
Original languageEnglish
Title of host publicationAntisense transcription associated with microRNA target mRNAs
StatePublished - May 9 2011


Dive into the research topics of 'Antisense transcription associated with microRNA target mRNAs'. Together they form a unique fingerprint.

Cite this