Antimicrobial sesquiterpene lactones from Artemisia sieberi

Tarik A. Mohamed, Mohamed Elamir Hegazy, Abeer A. Abd El Aty, Hazem A. Ghabbour, Mansour S. Alsaid, Abdelaaty A. Shahat, Paul Pare

Research output: Contribution to journalArticlepeer-review


© 2017 Informa UK Limited, trading as Taylor & Francis Group Two new sesquiterpene lactones 3R, 8R-dihydroxygermacr-4(15),9(10)-dien-6S,7S,11RH,12,6-olide (1) and 1R, 8S-dihydroxy-11R,13-dihydrobalchanin(2), together with two known compounds 11-epiartapshin (3) and 3′-hydroxygenkwanin (4), were isolated from Artemisia sieberi. Their structures were elucidated by 1D, 2D NMR, MS, and X-ray diffraction. Compound 4 inhibited Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus with Minimal inhibitory concentration values of 50 and 25 μg/disk, respectively. All the isolated compounds exhibited moderate antifungal activities.
Original languageEnglish
Pages (from-to)1-9
JournalJournal of Asian Natural Products Research
StatePublished - Mar 26 2017


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