TY - JOUR
T1 - Antimicrobial sesquiterpene lactones from Artemisia sieberi
AU - Mohamed, Tarik A.
AU - Hegazy, Mohamed Elamir F.
AU - Abd El Aty, Abeer A.
AU - Ghabbour, Hazem A.
AU - Alsaid, Mansour S.
AU - Shahat, Abdelaaty A.
AU - Paré, Paul W.
N1 - Publisher Copyright:
© 2017 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017/11/2
Y1 - 2017/11/2
N2 - Two new sesquiterpene lactones 3R, 8R-dihydroxygermacr-4(15),9(10)-dien-6S,7S,11RH,12,6-olide (1) and 1R, 8S-dihydroxy-11R,13-dihydrobalchanin(2), together with two known compounds 11-epiartapshin (3) and 3′-hydroxygenkwanin (4), were isolated from Artemisia sieberi. Their structures were elucidated by 1D, 2D NMR, MS, and X-ray diffraction. Compound 4 inhibited Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus with Minimal inhibitory concentration values of 50 and 25 μg/disk, respectively. All the isolated compounds exhibited moderate antifungal activities.
AB - Two new sesquiterpene lactones 3R, 8R-dihydroxygermacr-4(15),9(10)-dien-6S,7S,11RH,12,6-olide (1) and 1R, 8S-dihydroxy-11R,13-dihydrobalchanin(2), together with two known compounds 11-epiartapshin (3) and 3′-hydroxygenkwanin (4), were isolated from Artemisia sieberi. Their structures were elucidated by 1D, 2D NMR, MS, and X-ray diffraction. Compound 4 inhibited Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus with Minimal inhibitory concentration values of 50 and 25 μg/disk, respectively. All the isolated compounds exhibited moderate antifungal activities.
KW - Artemisia sieberi
KW - Asteraceae
KW - Sesquiterpenes
KW - X-rays analysis
KW - antimicrobial activity
UR - http://www.scopus.com/inward/record.url?scp=85016516046&partnerID=8YFLogxK
U2 - 10.1080/10286020.2017.1302939
DO - 10.1080/10286020.2017.1302939
M3 - Article
C2 - 28361549
AN - SCOPUS:85016516046
SN - 1028-6020
VL - 19
SP - 1093
EP - 1101
JO - Journal of Asian Natural Products Research
JF - Journal of Asian Natural Products Research
IS - 11
ER -