Antimicrobial sesquiterpene lactones from Artemisia sieberi

Tarik A. Mohamed, Mohamed Elamir F. Hegazy, Abeer A. Abd El Aty, Hazem A. Ghabbour, Mansour S. Alsaid, Abdelaaty A. Shahat, Paul W. Paré

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Two new sesquiterpene lactones 3R, 8R-dihydroxygermacr-4(15),9(10)-dien-6S,7S,11RH,12,6-olide (1) and 1R, 8S-dihydroxy-11R,13-dihydrobalchanin(2), together with two known compounds 11-epiartapshin (3) and 3′-hydroxygenkwanin (4), were isolated from Artemisia sieberi. Their structures were elucidated by 1D, 2D NMR, MS, and X-ray diffraction. Compound 4 inhibited Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus with Minimal inhibitory concentration values of 50 and 25 μg/disk, respectively. All the isolated compounds exhibited moderate antifungal activities.

Original languageEnglish
Pages (from-to)1093-1101
Number of pages9
JournalJournal of Asian Natural Products Research
Volume19
Issue number11
DOIs
StatePublished - Nov 2 2017

Keywords

  • Artemisia sieberi
  • Asteraceae
  • Sesquiterpenes
  • X-rays analysis
  • antimicrobial activity

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