TY - JOUR
T1 - Antigen-Specific Tolerization and Targeted Delivery as Therapeutic Strategies for Autoimmune Diseases
AU - Shakya, Akhilesh Kumar
AU - Nandakumar, Kutty Selva
N1 - Funding Information:
KSN received funds for his research (C1034211) from Southern Medical University, Guangzhou, China.
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/7
Y1 - 2018/7
N2 - The prevalence of autoimmune disorders is increasing steadily and there is no permanent cure available. Immunomodulation through repeated exposure of antigens, known as antigen-specific immune tolerance or antigen-specific immunotherapy (ASI), is a promising approach to treat or prevent autoimmune disorders. Different optimization protocols (immunization routes, delivery systems, and approaches) are being developed to implement ASI against self-proteins. Including appropriate adjuvants, altered peptide ligand, and using multipeptides are approaches that can be used to specifically target autoimmunity. This review explores various ASI application methods, including different routes of antigen-specific sensitization, delivery systems, immunomodulators containing specific antigens, and other targeted approaches that have been successfully demonstrated to have therapeutic effects on autoimmune diseases.
AB - The prevalence of autoimmune disorders is increasing steadily and there is no permanent cure available. Immunomodulation through repeated exposure of antigens, known as antigen-specific immune tolerance or antigen-specific immunotherapy (ASI), is a promising approach to treat or prevent autoimmune disorders. Different optimization protocols (immunization routes, delivery systems, and approaches) are being developed to implement ASI against self-proteins. Including appropriate adjuvants, altered peptide ligand, and using multipeptides are approaches that can be used to specifically target autoimmunity. This review explores various ASI application methods, including different routes of antigen-specific sensitization, delivery systems, immunomodulators containing specific antigens, and other targeted approaches that have been successfully demonstrated to have therapeutic effects on autoimmune diseases.
KW - antigen delivery systems
KW - antigen-specific immune tolerance
KW - autoimmune diseases
KW - routes of administration
UR - http://www.scopus.com/inward/record.url?scp=85044331253&partnerID=8YFLogxK
U2 - 10.1016/j.tibtech.2018.02.008
DO - 10.1016/j.tibtech.2018.02.008
M3 - Review article
C2 - 29588069
AN - SCOPUS:85044331253
VL - 36
SP - 686
EP - 699
JO - Trends in Biotechnology
JF - Trends in Biotechnology
SN - 0167-7799
IS - 7
ER -