TY - JOUR
T1 - Anticancer Activities of (-)-Epigallocatechin-3-Gallate Encapsulated Nanoliposomes in MCF7 Breast Cancer Cells
AU - Pace, Rita Castillo Cohen de
AU - Liu, Xinli
AU - Sun, Ming
AU - Nie, Shufang
AU - Zhang, Jia
AU - Cai, Qingsong
AU - Gao, Weimin
AU - Pan, Xuan
AU - Fan, Zhaoyang
AU - Wang, Shu
PY - 2013
Y1 - 2013
N2 - The chemopreventive actions exerted by green tea are thought to be due to its major
polyphenol, (-)-epigallocatechin-3-gallate (EGCG). However, the low level of stability and
bioavailability in the body makes administering EGCG at chemopreventive doses unrealistic. We
synthesized EGCG encapsulated chitosan-coated nanoliposomes (CSLIPO-EGCG), and observed their antiproliferative and proapoptotic effect in MCF7 breast cancer cells. CSLIPO-EGCG significantly increased EGCG stability, induced apoptosis of MCF7 cells, and inhibited MCF7 cell proliferation compared to native EGCG and void CSLIPO. The CSLIPO-EGCG retained its antiproliferative and
proapoptotic effectiveness at 10μM or lower, at which native EGCG doesn't have any beneficial effects. This study portends a potential breakthrough in the prevention or even treatment of breast cancer by using biocompatible and biodegradable CSLIPO-EGCG with enhanced chemopreventive efficacy and minimized immunogenicity and side-effects.
AB - The chemopreventive actions exerted by green tea are thought to be due to its major
polyphenol, (-)-epigallocatechin-3-gallate (EGCG). However, the low level of stability and
bioavailability in the body makes administering EGCG at chemopreventive doses unrealistic. We
synthesized EGCG encapsulated chitosan-coated nanoliposomes (CSLIPO-EGCG), and observed their antiproliferative and proapoptotic effect in MCF7 breast cancer cells. CSLIPO-EGCG significantly increased EGCG stability, induced apoptosis of MCF7 cells, and inhibited MCF7 cell proliferation compared to native EGCG and void CSLIPO. The CSLIPO-EGCG retained its antiproliferative and
proapoptotic effectiveness at 10μM or lower, at which native EGCG doesn't have any beneficial effects. This study portends a potential breakthrough in the prevention or even treatment of breast cancer by using biocompatible and biodegradable CSLIPO-EGCG with enhanced chemopreventive efficacy and minimized immunogenicity and side-effects.
M3 - Article
SP - 187
EP - 196
JO - Journal of Liposome Research
JF - Journal of Liposome Research
ER -