Anticancer Activities of (-)-Epigallocatechin-3-Gallate Encapsulated Nanoliposomes in MCF7 Breast Cancer Cells

Rita Castillo Cohen de Pace, Xinli Liu, Ming Sun, Shufang Nie, Jia Zhang, Qingsong Cai, Weimin Gao, Xuan Pan, Zhaoyang Fan, Shu Wang

Research output: Contribution to journalArticle

Abstract

The chemopreventive actions exerted by green tea are thought to be due to its major polyphenol, (-)-epigallocatechin-3-gallate (EGCG). However, the low level of stability and bioavailability in the body makes administering EGCG at chemopreventive doses unrealistic. We synthesized EGCG encapsulated chitosan-coated nanoliposomes (CSLIPO-EGCG), and observed their antiproliferative and proapoptotic effect in MCF7 breast cancer cells. CSLIPO-EGCG significantly increased EGCG stability, induced apoptosis of MCF7 cells, and inhibited MCF7 cell proliferation compared to native EGCG and void CSLIPO. The CSLIPO-EGCG retained its antiproliferative and proapoptotic effectiveness at 10μM or lower, at which native EGCG doesn't have any beneficial effects. This study portends a potential breakthrough in the prevention or even treatment of breast cancer by using biocompatible and biodegradable CSLIPO-EGCG with enhanced chemopreventive efficacy and minimized immunogenicity and side-effects.
Original languageEnglish
Pages (from-to)187-196
JournalJournal of Liposome Research
StatePublished - 2013

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