Anti-inflammatory sesquiterpenes from the medicinal herb Tanacetum sinaicum

Mohamed-Elamir F Hegazy, Ahmed R Hamed, Tarik A Mohamed, Abdessamad Debbab, Seikou Nakamura, Hisashi Matsuda, Paul Pare

Research output: Contribution to journalArticlepeer-review


New sesquiterpenes tanacetolide A–C (1–3) were isolated from a Tanacetum sinaicum extract together with known compounds (4–10). The structures were elucidated on the basis of MS and NMR spectroscopic data. All the compounds were evaluated for the inhibition of inducible nitric oxide (NO) production in a mouse peritoneal macrophage system. Iso-seco-tanapartholide-3-O-methyl ether (4) produced potent inhibition of NO production (IC50 = 1.0 μM). At the protein expression level, 4 elicited concentration-dependant down-regulation of inducible nitric oxide synthase.
Original languageEnglish
Pages (from-to)44895-44901
JournalRSC Advances
StatePublished - 2015


Dive into the research topics of 'Anti-inflammatory sesquiterpenes from the medicinal herb Tanacetum sinaicum'. Together they form a unique fingerprint.

Cite this