Anti-inflammatory sesquiterpenes from the medicinal herb Tanacetum sinaicum

Mohamed-Elamir F Hegazy, Ahmed R Hamed, Tarik A Mohamed, Abdessamad Debbab, Seikou Nakamura, Hisashi Matsuda, Paul Pare

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Abstract

New sesquiterpenes tanacetolide A–C (1–3) were isolated from a Tanacetum sinaicum extract together with known compounds (4–10). The structures were elucidated on the basis of MS and NMR spectroscopic data. All the compounds were evaluated for the inhibition of inducible nitric oxide (NO) production in a mouse peritoneal macrophage system. Iso-seco-tanapartholide-3-O-methyl ether (4) produced potent inhibition of NO production (IC50 = 1.0 μM). At the protein expression level, 4 elicited concentration-dependant down-regulation of inducible nitric oxide synthase.
Original languageEnglish
Pages (from-to)44895-44901
JournalRSC Advances
StatePublished - 2015

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Hegazy, M-E. F., Hamed, A. R., Mohamed, T. A., Debbab, A., Nakamura, S., Matsuda, H., & Pare, P. (2015). Anti-inflammatory sesquiterpenes from the medicinal herb Tanacetum sinaicum. RSC Advances, 44895-44901.