Anti-inflammatory sesquiterpenes from the medicinal herb Tanacetum sinaicum

Mohamed Elamir F. Hegazy, Ahmed R. Hamed, Tarik A. Mohamed, Abdessamad Debbab, Seikou Nakamura, Hisashi Matsuda, Paul W. Paré

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6 Scopus citations

Abstract

New sesquiterpenes tanacetolide A-C (1-3) were isolated from a Tanacetum sinaicum extract together with known compounds (4-10). The structures were elucidated on the basis of MS and NMR spectroscopic data. All the compounds were evaluated for the inhibition of inducible nitric oxide (NO) production in a mouse peritoneal macrophage system. Iso-seco-tanapartholide-3-O-methyl ether (4) produced potent inhibition of NO production (IC50 = 1.0 μM). At the protein expression level, 4 elicited concentration-dependant down-regulation of inducible nitric oxide synthase.

Original languageEnglish
Pages (from-to)44895-44901
Number of pages7
JournalRSC Advances
Volume5
Issue number56
DOIs
StatePublished - 2015

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    Hegazy, M. E. F., Hamed, A. R., Mohamed, T. A., Debbab, A., Nakamura, S., Matsuda, H., & Paré, P. W. (2015). Anti-inflammatory sesquiterpenes from the medicinal herb Tanacetum sinaicum. RSC Advances, 5(56), 44895-44901. https://doi.org/10.1039/c5ra07511d