Abstract
New sesquiterpenes tanacetolide A-C (1-3) were isolated from a Tanacetum sinaicum extract together with known compounds (4-10). The structures were elucidated on the basis of MS and NMR spectroscopic data. All the compounds were evaluated for the inhibition of inducible nitric oxide (NO) production in a mouse peritoneal macrophage system. Iso-seco-tanapartholide-3-O-methyl ether (4) produced potent inhibition of NO production (IC50 = 1.0 μM). At the protein expression level, 4 elicited concentration-dependant down-regulation of inducible nitric oxide synthase.
Original language | English |
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Pages (from-to) | 44895-44901 |
Number of pages | 7 |
Journal | RSC Advances |
Volume | 5 |
Issue number | 56 |
DOIs | |
State | Published - 2015 |