Anti-inflammatory sesquiterpenes from the medicinal herb Tanacetum sinaicum

Mohamed Elamir F. Hegazy; Ahmed R. Hamed; Tarik A. Mohamed; Abdessamad Debbab; Seikou Nakamura; Hisashi Matsuda; Paul W. Paré

doi:10.1039/c5ra07511d

Anti-inflammatory sesquiterpenes from the medicinal herb Tanacetum sinaicum

Mohamed Elamir F. Hegazy, Ahmed R. Hamed, Tarik A. Mohamed, Abdessamad Debbab, Seikou Nakamura, Hisashi Matsuda, Paul W. Paré

Chemistry and Biochemistry

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19 Scopus citations

Abstract

New sesquiterpenes tanacetolide A-C (1-3) were isolated from a Tanacetum sinaicum extract together with known compounds (4-10). The structures were elucidated on the basis of MS and NMR spectroscopic data. All the compounds were evaluated for the inhibition of inducible nitric oxide (NO) production in a mouse peritoneal macrophage system. Iso-seco-tanapartholide-3-O-methyl ether (4) produced potent inhibition of NO production (IC₅₀ = 1.0 μM). At the protein expression level, 4 elicited concentration-dependant down-regulation of inducible nitric oxide synthase.

Original language	English
Pages (from-to)	44895-44901
Number of pages	7
Journal	RSC Advances
Volume	5
Issue number	56
DOIs	https://doi.org/10.1039/c5ra07511d
State	Published - 2015

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title = "Anti-inflammatory sesquiterpenes from the medicinal herb Tanacetum sinaicum",

abstract = "New sesquiterpenes tanacetolide A-C (1-3) were isolated from a Tanacetum sinaicum extract together with known compounds (4-10). The structures were elucidated on the basis of MS and NMR spectroscopic data. All the compounds were evaluated for the inhibition of inducible nitric oxide (NO) production in a mouse peritoneal macrophage system. Iso-seco-tanapartholide-3-O-methyl ether (4) produced potent inhibition of NO production (IC50 = 1.0 μM). At the protein expression level, 4 elicited concentration-dependant down-regulation of inducible nitric oxide synthase.",

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AU - Hegazy, Mohamed Elamir F.

AU - Hamed, Ahmed R.

AU - Mohamed, Tarik A.

AU - Debbab, Abdessamad

AU - Nakamura, Seikou

AU - Matsuda, Hisashi

AU - Paré, Paul W.

PY - 2015

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AB - New sesquiterpenes tanacetolide A-C (1-3) were isolated from a Tanacetum sinaicum extract together with known compounds (4-10). The structures were elucidated on the basis of MS and NMR spectroscopic data. All the compounds were evaluated for the inhibition of inducible nitric oxide (NO) production in a mouse peritoneal macrophage system. Iso-seco-tanapartholide-3-O-methyl ether (4) produced potent inhibition of NO production (IC50 = 1.0 μM). At the protein expression level, 4 elicited concentration-dependant down-regulation of inducible nitric oxide synthase.

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JO - RSC Advances

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SN - 2046-2069

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ER -

Anti-inflammatory sesquiterpenes from the medicinal herb Tanacetum sinaicum

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