Anti-inflammatory sesquiterpenes from the medicinal herb Tanacetum sinaicum

Mohamed Elamir F. Hegazy; Ahmed R. Hamed; Tarik A. Mohamed; Abdessamad Debbab; Seikou Nakamura; Hisashi Matsuda; Paul W. Paré

doi:10.1039/c5ra07511d

Anti-inflammatory sesquiterpenes from the medicinal herb Tanacetum sinaicum

Mohamed Elamir F. Hegazy, Ahmed R. Hamed, Tarik A. Mohamed, Abdessamad Debbab, Seikou Nakamura, Hisashi Matsuda, Paul W. Paré

Chemistry and Biochemistry

Research output: Contribution to journal › Article

6 Scopus citations

Abstract

New sesquiterpenes tanacetolide A-C (1-3) were isolated from a Tanacetum sinaicum extract together with known compounds (4-10). The structures were elucidated on the basis of MS and NMR spectroscopic data. All the compounds were evaluated for the inhibition of inducible nitric oxide (NO) production in a mouse peritoneal macrophage system. Iso-seco-tanapartholide-3-O-methyl ether (4) produced potent inhibition of NO production (IC₅₀ = 1.0 μM). At the protein expression level, 4 elicited concentration-dependant down-regulation of inducible nitric oxide synthase.

Original language	English
Pages (from-to)	44895-44901
Number of pages	7
Journal	RSC Advances
Volume	5
Issue number	56
DOIs	https://doi.org/10.1039/c5ra07511d
State	Published - 2015

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Hegazy, M. E. F., Hamed, A. R., Mohamed, T. A., Debbab, A., Nakamura, S., Matsuda, H., & Paré, P. W. (2015). Anti-inflammatory sesquiterpenes from the medicinal herb Tanacetum sinaicum. RSC Advances, 5(56), 44895-44901. https://doi.org/10.1039/c5ra07511d

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AU - Nakamura, Seikou

AU - Matsuda, Hisashi

AU - Paré, Paul W.

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