Anti-inflammatory activity of new guaiane acid derivatives from Achillea coarctata

Mohamed Elamir F. Hegazy, Ahmed Abdel-Lateff, Amira M. Gamal-Eldeen, Fatma Turky, Toshifumi Hirata, Paul W. Paré, Joe Karchesy, Mohamed S. Kamel, Ahmed A. Ahmed

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Chromatographic investigation of the methylene chloride/methanol extract of aerial parts of Achillea coarctata afforded two new guaiane acid derivatives, 1α,6α,8α-trihydroxy-5α,7βH-guaia-3,10(14),11(13) -trien-12-oic acid (1) and 1α,6α,8α-trihydroxy-5α, 7βH-guaia-3,9,11(13)-trien-12-oic acid (2), in addition to three known compounds, ligustolide-A (3), arteludovicinolide-A (4) and austricin (5). Structures were elucidated by spectroscopic analyses including: 1H and 13C NMR, COSY, HMQC, HMBC and NOESY NMR spectroscopy, as well as MS analysis. Proliferation of beneficial macrophages was significantly enhanced by treatment with 1 and 2. Additionally, treatment with compounds 2 and 4 led to a potentially significant inhibition in nitric oxide generation from raw murine macrophage 264.7, which was stimulated by bacterial lipopolysaccharide. Compounds 2 and 4 exhibited anti-inflammatory properties, based on a nitric oxide assay.

Original languageEnglish
Pages (from-to)851-856
Number of pages6
JournalNatural Product Communications
Volume3
Issue number6
DOIs
StatePublished - 2008

Keywords

  • Achillea coarctata
  • Anti-inflammatory activity
  • Asteraceae
  • Macrophage proliferation
  • Sesquiterpenes

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