Ankyrin Is An Intracellular Tether for TMC Mechanotransduction Channels

Yi Quan Tang; Sol Ah Lee; Mizanur Rahman; Siva A. Vanapalli; Hang Lu; William R. Schafer

doi:10.1016/j.neuron.2020.03.026

Ankyrin Is An Intracellular Tether for TMC Mechanotransduction Channels

Yi Quan Tang, Sol Ah Lee, Mizanur Rahman, Siva A. Vanapalli, Hang Lu, William R. Schafer

Chemical Engineering

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

TMC channels are important for sensory transduction, notably as key components of the hair cell mechanotransducer. In this issue of Neuron, Tang et al. show that the mechanosensory activity of C. elegans TMCs requires the intracellular tether ankyrin, which interacts with TMC-1 through the adaptor protein CALM-1.

Original language	English
Pages (from-to)	112-125.e10
Journal	Neuron
Volume	107
Issue number	1
DOIs	https://doi.org/10.1016/j.neuron.2020.03.026
State	Published - Jul 8 2020

Keywords

C. elegans
CIB
TMC
ankyrin
gating spring
hair cells
mechanotransduction channel
nose touch
tether

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10.1016/j.neuron.2020.03.026

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abstract = "TMC channels are important for sensory transduction, notably as key components of the hair cell mechanotransducer. In this issue of Neuron, Tang et al. show that the mechanosensory activity of C. elegans TMCs requires the intracellular tether ankyrin, which interacts with TMC-1 through the adaptor protein CALM-1.",

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AU - Lu, Hang

AU - Schafer, William R.

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KW - TMC

KW - ankyrin

KW - gating spring

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Ankyrin Is An Intracellular Tether for TMC Mechanotransduction Channels

Abstract

Keywords

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