Ankyrin Is An Intracellular Tether for TMC Mechanotransduction Channels

Yi Quan Tang, Sol Ah Lee, Mizanur Rahman, Siva A. Vanapalli, Hang Lu, William R. Schafer

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


TMC channels are important for sensory transduction, notably as key components of the hair cell mechanotransducer. In this issue of Neuron, Tang et al. show that the mechanosensory activity of C. elegans TMCs requires the intracellular tether ankyrin, which interacts with TMC-1 through the adaptor protein CALM-1.

Original languageEnglish
Pages (from-to)112-125.e10
Issue number1
StatePublished - Jul 8 2020


  • C. elegans
  • CIB
  • TMC
  • ankyrin
  • gating spring
  • hair cells
  • mechanotransduction channel
  • nose touch
  • tether


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