TY - GEN
T1 - Analyzing pathway design from drug perturbation experiments
AU - Berlow, Noah
AU - Pal, Ranadip
AU - Davis, Lara
AU - Keller, Charles
PY - 2012
Y1 - 2012
N2 - Drugs that target specific kinases are becoming common in cancer research. In this article, we analyze the design of a modeling approach for drug sensitivity prediction and combination targeted therapy design based on drug perturbation experiments. We consider a target inhibition map model that predicts the tumor sensitivities for all possible combination of target inhibitions. The estimation of the model is based on experimental sensitivity data for multiple target inhibitory drugs. The target inhibition map model provides a steady-state snapshot of the underlying dynamical model. To analyze the robustness of the combination therapy design approach, we consider the inverse problem of possible dynamic models that can generate the target inhibition map model and their transient and steady state response to drugs. We showed that the knowledge of the steady state target inhibition map can be used to estimate the directional pathway using a small number of steady state target expression measurements.
AB - Drugs that target specific kinases are becoming common in cancer research. In this article, we analyze the design of a modeling approach for drug sensitivity prediction and combination targeted therapy design based on drug perturbation experiments. We consider a target inhibition map model that predicts the tumor sensitivities for all possible combination of target inhibitions. The estimation of the model is based on experimental sensitivity data for multiple target inhibitory drugs. The target inhibition map model provides a steady-state snapshot of the underlying dynamical model. To analyze the robustness of the combination therapy design approach, we consider the inverse problem of possible dynamic models that can generate the target inhibition map model and their transient and steady state response to drugs. We showed that the knowledge of the steady state target inhibition map can be used to estimate the directional pathway using a small number of steady state target expression measurements.
UR - http://www.scopus.com/inward/record.url?scp=84868238241&partnerID=8YFLogxK
U2 - 10.1109/SSP.2012.6319757
DO - 10.1109/SSP.2012.6319757
M3 - Conference contribution
AN - SCOPUS:84868238241
SN - 9781467301831
T3 - 2012 IEEE Statistical Signal Processing Workshop, SSP 2012
SP - 552
EP - 555
BT - 2012 IEEE Statistical Signal Processing Workshop, SSP 2012
T2 - 2012 IEEE Statistical Signal Processing Workshop, SSP 2012
Y2 - 5 August 2012 through 8 August 2012
ER -