Analysis of cell membrane permeabilization mechanics and pore shape due to ultrashort electrical pulsing

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Abstract

Cell membrane permeabilization mechanics and the resulting shape of nanopores in response to electrical pulsing are probed based on a continuum approach. This has implications for electropermeabilization and cell membrane transport. It is argued that small pores resulting from high-intensity (~100 kV/cm), nanosecond pulsing would have an initial asymmetric shape. This would lead to asymmetric membrane current-voltage characteristics, at least at early times. The role of the cytoskeleton is ignored here, but can be expected to additionally contribute to such asymmetries. Furthermore, we show that the pore shape and membrane conduction would be dynamic, and evolve toward a symmetric characteristic over time. This duration has been shown to be in the micro-second range.

Original languageEnglish
Pages (from-to)837-844
Number of pages8
JournalMedical and Biological Engineering and Computing
Volume48
Issue number9
DOIs
StatePublished - Sep 2010

Keywords

  • Bioelectrics
  • Electroporation
  • Modeling
  • Nanosecond pulsing
  • Pore shape

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