Tuberculosis is still a global threat to humans. In this letter, we analyzed a four-dimensional with-in host tuberculosis infection model and obtain thresholds for basic reproduction number, forward bifurcation, and backward bifurcation. Global sensitivity analysis provides parameters, which significantly influence the model dynamics. Bifurcation analysis and diagrams show parameter regions for disease elimination, latency, and active disease. Numerical simulations prove analytical results and demonstrate bistable model dynamics.
- 2-dimensional bifurcation diagram
- Bifurcation analysis
- Global sensitivity analysis
- Tuberculosis model