Analysis of a dual shock-wave and ultrashort electric pulsing strategy for electro-manipulation of membrane nanopores

Q. Hu, S. Hossain, R. P. Joshi

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Electric pulse driven membrane poration finds applications in the fields of biomedical engineering and drug/gene delivery. Shock waves are known to permeabilize cell membranes as well. Here we focus on and analyze the synergistic effects of both inputs in concert based on molecular dynamics simulations. Our results show that shockwaves could be used for pretreating cell membranes for electroporation. The dual strategy would either reduce the external voltage requirements (leading to more compact external circuitry) or help create larger pores. Furthermore, shockwaves could form pores at any desired membrane site location, and suitable combinations of nanojets and electric pulses would help control the aspect ratio and size as desired.

Original languageEnglish
Article number285403
JournalJournal of Physics D: Applied Physics
Volume51
Issue number28
DOIs
StatePublished - Jun 25 2018

Keywords

  • bioelectrics
  • cellular uptake
  • electroporation
  • molecular dynamics
  • nanosecond

Fingerprint Dive into the research topics of 'Analysis of a dual shock-wave and ultrashort electric pulsing strategy for electro-manipulation of membrane nanopores'. Together they form a unique fingerprint.

  • Cite this