An update on smart biocatalysts for industrial and biomedical applications

Akhilesh Kumar Shakya, Kutty Selva Nandakumar

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


Recently, smart biocatalysts, where enzymes are conjugated to stimuli-responsive (smart) polymers, have gained significant attention. Based on the presence or absence of external stimuli, the polymer attached to the enzyme changes its conformation to protect the enzyme from the external environment and regulate the enzyme activity, thus acting as a molecular switch. Owing to this behaviour, smart biocatalysts can be separated easily from a reaction mixture and re-used several times. Several such smart polymer-based biocatalysts have been developed for industrial and biomedical applications. In addition, they have been used in biosensors, biometrics and nano-electronic devices. This review article covers recent advances in developing different kinds of stimuli-responsive enzyme bioconjugates, including conjugation strategies, and their applications.

Original languageEnglish
Article number20180062
JournalJournal of the Royal Society Interface
Issue number139
StatePublished - 2018


  • Industrial biocatalyst
  • Magnetic smart biocatalyst
  • Responsive polymer
  • Smart biocatalyst
  • Therapeutic biocatalyst
  • Thermo-responsive biocatalyst


Dive into the research topics of 'An update on smart biocatalysts for industrial and biomedical applications'. Together they form a unique fingerprint.

Cite this