An observational study of the association between adenovirus 36 antibody status and weight loss among youth

Jillon S. Vander Wal, Jean Huelsing, Olga Dubuisson, Nikhil V. Dhurandhar

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Objective: Although the human adenovirus 36 (Ad-36) is associated with obesity and relative hypolipidemia, its role in pediatric weight loss treatment response is uncertain. Therefore, the primary study objective was to determine whether Ad-36 antibody (AB) status was associated with response to a pediatric weight loss program. The secondary objective was to assess the association between Ad-36 AB status and baseline lipid values. Methods: Participants included 73 youth aged 10-17 years in a residential camp-based weight loss program. The study examined differences in baseline lipid values between Ad-36 AB+ and AB- youth as well as differences in response to treatment, including indices of body size and fitness. Results: At baseline, results showed that Ad-36 AB+ youth evidenced significantly lower levels of total cholesterol and triglycerides than Ad-36 AB- youth (all p < 0.05). After 4 weeks of treatment, the Ad-36 AB+ youth showed a smaller reduction in BMI percentile than the Ad-36 AB- youth (p < 0.05), a difference of about 0.48 kg. Conclusion: Ad-36 AB status showed a weak association with treatment response, but was associated with a better lipid profile. Ad-36 AB status should be assessed in studies of pediatric obesity treatment and prevention.

Original languageEnglish
Pages (from-to)269-278
Number of pages10
JournalObesity Facts
Volume6
Issue number3
DOIs
StatePublished - 2013

Keywords

  • Ad-36
  • Adenoviruses
  • Lipids
  • Obesity
  • Pediatrics
  • Physical fitness
  • Weight loss

Fingerprint Dive into the research topics of 'An observational study of the association between adenovirus 36 antibody status and weight loss among youth'. Together they form a unique fingerprint.

Cite this