TY - JOUR
T1 - An expanded view of energy homeostasis
T2 - Neural integration of metabolic, cognitive, and emotional drives to eat
AU - Shin, Andrew C.
AU - Zheng, Huiyuan
AU - Berthoud, Hans Rudolf
PY - 2009/7/14
Y1 - 2009/7/14
N2 - The traditional view of neural regulation of body energy homeostasis focuses on internal feedback signals integrated in the hypothalamus and brainstem and in turn leading to balanced activation of behavioral, autonomic, and endocrine effector pathways leading to changes in food intake and energy expenditure. Recent observations have demonstrated that many of these internal signals encoding energy status have much wider effects on the brain, particularly sensory and cortico-limbic systems that process information from the outside world by detecting and interpreting food cues, forming, storing, and recalling representations of experience with food, and assigning hedonic and motivational value to conditioned and unconditioned food stimuli. Thus, part of the metabolic feedback from the internal milieu regulates food intake and energy balance by acting on extrahypothalamic structures, leading to an expanded view of neural control of energy homeostasis taking into account the need to adapt to changing conditions in the environment. The realization that metabolic signals act directly on these non-traditional targets of body energy homeostasis brings opportunities for novel drug targets for the fight against obesity and eating disorders.
AB - The traditional view of neural regulation of body energy homeostasis focuses on internal feedback signals integrated in the hypothalamus and brainstem and in turn leading to balanced activation of behavioral, autonomic, and endocrine effector pathways leading to changes in food intake and energy expenditure. Recent observations have demonstrated that many of these internal signals encoding energy status have much wider effects on the brain, particularly sensory and cortico-limbic systems that process information from the outside world by detecting and interpreting food cues, forming, storing, and recalling representations of experience with food, and assigning hedonic and motivational value to conditioned and unconditioned food stimuli. Thus, part of the metabolic feedback from the internal milieu regulates food intake and energy balance by acting on extrahypothalamic structures, leading to an expanded view of neural control of energy homeostasis taking into account the need to adapt to changing conditions in the environment. The realization that metabolic signals act directly on these non-traditional targets of body energy homeostasis brings opportunities for novel drug targets for the fight against obesity and eating disorders.
KW - Appetite
KW - Food hedonics
KW - Food reward
KW - Gut hormones
KW - Hypothalamus
KW - Motivation
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=68649091204&partnerID=8YFLogxK
U2 - 10.1016/j.physbeh.2009.02.010
DO - 10.1016/j.physbeh.2009.02.010
M3 - Article
C2 - 19419661
AN - SCOPUS:68649091204
VL - 97
SP - 572
EP - 580
JO - Physiology and Behavior
JF - Physiology and Behavior
SN - 0031-9384
IS - 5
ER -