An effective method for allylic oxidation of Delta-5-steroids using tert-butyl hydroperoxide

Yuancheng Li, Xianghong Wu, Tae Bum Lee, Eleanor K Isbell, Edward J Parish, Anne Gorden

Research output: Contribution to journalArticlepeer-review

Abstract

An allylic oxidation method for Δ5-steroids using TBHP as oxidant with a 2-quinoxalinol salen Cu(II) complex as catalyst is reported. A variety of Δ5-steroidal substrates are selectively oxidized to the corresponding enones. Excellent yields are achieved (up to 99% under optimized conditions) while significantly reducing reaction times required as compared to other current methods.
Original languageEnglish
Pages (from-to)1807--1810
JournalJournal of Organic Chemistry
DOIs
StatePublished - 2010

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