Ammonium Iodide Induced Nonradical Regioselective Sulfenylation of Flavones via a C-H Functionalization Process

Wannian Zhao; Ping Xie; Zhaogang Bian; Aihua Zhou; Haibo Ge; Min Zhang; Yingcai Ding; Lian Zheng

doi:10.1021/acs.joc.5b01602

Ammonium Iodide Induced Nonradical Regioselective Sulfenylation of Flavones via a C-H Functionalization Process

Wannian Zhao, Ping Xie, Zhaogang Bian, Aihua Zhou, Haibo Ge, Min Zhang, Yingcai Ding, Lian Zheng

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

A novel and highly regioselective ammonium iodide-induced nonradical sulfenylation method for the construction of a C-S bond was developed via C-H functionalization. With DMSO or R¹SO₂NHNH₂ as a sulfenylating agent, MeS- and R¹S-substituted flavone derivatives were obtained in good yields. This method enriches current C-S bond formation chemistry, making it a highly valuable and practical method in pharmaceutical industry.

Original language	English
Pages (from-to)	9167-9175
Number of pages	9
Journal	Journal of Organic Chemistry
Volume	80
Issue number	18
DOIs	https://doi.org/10.1021/acs.joc.5b01602
State	Published - Sep 18 2015

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abstract = "A novel and highly regioselective ammonium iodide-induced nonradical sulfenylation method for the construction of a C-S bond was developed via C-H functionalization. With DMSO or R1SO2NHNH2 as a sulfenylating agent, MeS- and R1S-substituted flavone derivatives were obtained in good yields. This method enriches current C-S bond formation chemistry, making it a highly valuable and practical method in pharmaceutical industry.",

author = "Wannian Zhao and Ping Xie and Zhaogang Bian and Aihua Zhou and Haibo Ge and Min Zhang and Yingcai Ding and Lian Zheng",

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AU - Zhao, Wannian

AU - Xie, Ping

AU - Bian, Zhaogang

AU - Zhou, Aihua

AU - Ge, Haibo

AU - Zhang, Min

AU - Ding, Yingcai

AU - Zheng, Lian

PY - 2015/9/18

Y1 - 2015/9/18

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AB - A novel and highly regioselective ammonium iodide-induced nonradical sulfenylation method for the construction of a C-S bond was developed via C-H functionalization. With DMSO or R1SO2NHNH2 as a sulfenylating agent, MeS- and R1S-substituted flavone derivatives were obtained in good yields. This method enriches current C-S bond formation chemistry, making it a highly valuable and practical method in pharmaceutical industry.

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 18

ER -

Ammonium Iodide Induced Nonradical Regioselective Sulfenylation of Flavones via a C-H Functionalization Process

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