Aminochlorination reaction with N-chlorophthalimide as a new nitrogen/chlorine source resulting in α-amino derivatives

Yu Qian, Xiaoyun Ji, Wei Zhou, Jianlin Han, Guigen Li, Yi Pan

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

A commercial available compound, N-chlorophthalimide was reported as an efficient nitrogen/chlorine source for the aminohalogenation of β-nitrostyrenes, which tolerates a wide range of β-nitrostyrenes substrates with good chemical yields, as well as excellent regioselectivities. The resulted vicinal haloamino nitro products have been converted into several other valuable α-amino compounds under simple and mild conditions.

Original languageEnglish
Pages (from-to)6198-6203
Number of pages6
JournalTetrahedron
Volume68
Issue number31
DOIs
StatePublished - Aug 5 2012

Keywords

  • Aminohalogenation
  • N-Chlorophthalimide
  • α-Amino compounds
  • β-Nitrostyrenes

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