TY - GEN

T1 - Altering steady-state probabilities in probabilistic Boolean networks

AU - Pal, Ranadip

AU - Datta, Aniruddha

AU - Dougherty, Edward R.

PY - 2006

Y1 - 2006

N2 - External control of a genetic regulatory network is used for the purpose of avoiding undesirable states, such as those associated with disease. Heretofore, intervention has focused on finite-horizon control, i.e., control over a small number of stages. This paper considers the design of optimal infinite-horizon control for Probabilistic Boolean Networks (PBNs). The stationary policy obtained is independent of time and dependent on the current state. The average-cost-per-stage problem formulation is used to generate the stationary policy for a PBN constructed from melanoma gene-expression data. The results show that the stationary policiy obtained is capable of shifting the probability mass of the stationary distribution from undesirable states to desirable ones.

AB - External control of a genetic regulatory network is used for the purpose of avoiding undesirable states, such as those associated with disease. Heretofore, intervention has focused on finite-horizon control, i.e., control over a small number of stages. This paper considers the design of optimal infinite-horizon control for Probabilistic Boolean Networks (PBNs). The stationary policy obtained is independent of time and dependent on the current state. The average-cost-per-stage problem formulation is used to generate the stationary policy for a PBN constructed from melanoma gene-expression data. The results show that the stationary policiy obtained is capable of shifting the probability mass of the stationary distribution from undesirable states to desirable ones.

UR - http://www.scopus.com/inward/record.url?scp=48649090440&partnerID=8YFLogxK

U2 - 10.1109/GENSIPS.2006.353163

DO - 10.1109/GENSIPS.2006.353163

M3 - Conference contribution

AN - SCOPUS:48649090440

SN - 1424403855

SN - 9781424403851

T3 - 2006 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS 2006

SP - 75

EP - 76

BT - 2006 IEEE International Workshop on Genomic Signal Processing and Statstics, GENSIPS 2006

T2 - 2006 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS 2006

Y2 - 28 May 2006 through 30 May 2006

ER -