Allylic C--H Activations Using Cu (II) 2-Quinoxalinol Salen and tert-Butyl Hydroperoxide

Yuancheng Li, Tae Bum Lee, Tanyu Wang, Audrey V Gamble, Anne Gorden

Research output: Contribution to journalArticlepeer-review

Abstract

Using a Cu(II) 2-quinoxalinol salen complex as the catalyst and tert-butyl hydroperoxide (TBHP) as the oxidant, allylic activations of olefin substrates can be converted to the corresponding enones or 1,4-enediones. Excellent yields can be achieved (up to 99%) within a very short reaction time and with great tolerance for additional functional groups. Possible mechanistic pathways have been characterized using Raman spectroscopy, cyclic voltammetry, and theoretical calculations.
Original languageEnglish
Pages (from-to)4628--4633
JournalJournal of Organic Chemistry
DOIs
StatePublished - 2012

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