Allylic amination and N-arylation-based domino reactions providing rapid three-component strategies to fused pyrroles with different substituted patterns

Bo Jiang, Ying Li, Man Su Tu, Shu Liang Wang, Shu Jiang Tu, Guigen Li

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

New three-component domino reaction providing divergent approaches to multifunctionalized fused pyrroles with different substituted patterns have been established (40 examples). The direct C(sp3)-N bond formation was achieved through intermolecular allylic amination in a one-pot operation, and N-arylation of amines was realized by varying N-amino acid enaminones. The reaction is easy to perform simply by mixing three common reactants in acetic acid under microwave heating. The reaction proceeds at fast rates and can be finished within 30 min, which makes workup convenient to give good chemical yields.

Original languageEnglish
Pages (from-to)7497-7505
Number of pages9
JournalJournal of Organic Chemistry
Volume77
Issue number17
DOIs
StatePublished - Sep 7 2012

Fingerprint Dive into the research topics of 'Allylic amination and N-arylation-based domino reactions providing rapid three-component strategies to fused pyrroles with different substituted patterns'. Together they form a unique fingerprint.

  • Cite this