TY - JOUR
T1 - Airborne Particulate Matter
T2 - Human Exposure and Health Effects
AU - Thompson, Jonathan E.
N1 - Publisher Copyright:
© 2018 American College of Occupational and Environmental Medicine.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Objective: Exposure to airborne particulate matter (PM) is estimated to cause millions of premature deaths annually. This work conveys known routes of exposure to PM and resultant health effects. Methods: A review of available literature. Results: Estimates for daily PM exposure are provided. Known mechanisms by which insoluble particles are transported and removed from the body are discussed. Biological effects of PM, including immune response, cytotoxicity, and mutagenicity, are reported. Epidemiological studies that outline the systemic health effects of PM are presented. Conclusion: While the integrated, per capita, exposure of PM for a large fraction of the first-world may be less than 1mg per day, links between several syndromes, including attention deficit hyperactivity disorder (ADHD), autism, loss of cognitive function, anxiety, asthma, chronic obstructive pulmonary disease (COPD), hypertension, stroke, and PM exposure have been suggested. This article reviews and summarizes such links reported in the literature.
AB - Objective: Exposure to airborne particulate matter (PM) is estimated to cause millions of premature deaths annually. This work conveys known routes of exposure to PM and resultant health effects. Methods: A review of available literature. Results: Estimates for daily PM exposure are provided. Known mechanisms by which insoluble particles are transported and removed from the body are discussed. Biological effects of PM, including immune response, cytotoxicity, and mutagenicity, are reported. Epidemiological studies that outline the systemic health effects of PM are presented. Conclusion: While the integrated, per capita, exposure of PM for a large fraction of the first-world may be less than 1mg per day, links between several syndromes, including attention deficit hyperactivity disorder (ADHD), autism, loss of cognitive function, anxiety, asthma, chronic obstructive pulmonary disease (COPD), hypertension, stroke, and PM exposure have been suggested. This article reviews and summarizes such links reported in the literature.
KW - PM10
KW - PM2.5
KW - aerosol
KW - health effects of pollution
KW - immune response
KW - inflammation
KW - particulate matter
UR - http://www.scopus.com/inward/record.url?scp=85046677959&partnerID=8YFLogxK
U2 - 10.1097/JOM.0000000000001277
DO - 10.1097/JOM.0000000000001277
M3 - Article
C2 - 29334526
AN - SCOPUS:85046677959
SN - 1076-2752
VL - 60
SP - 392
EP - 423
JO - Journal of Occupational and Environmental Medicine
JF - Journal of Occupational and Environmental Medicine
IS - 5
ER -