@article{8b3e98a2d1b14e528dd935d183f6249a,
title = "Ag/Br{\o}nsted Acid Co-Catalyzed Spiroketalization of β-Alkynyl Ketones toward Spiro[chromane-2,1′-isochromene] Derivatives",
abstract = "A new Ag/Br{\o}nsted acid co-catalyzed spiroketalization of β-alkynyl ketones with para-quinone methides (p-QMs) has been established, enabling multiple C-C and C-O bond-forming events to access densely functionalized spiro[chromane-2,1′-isochromene] derivatives with generally excellent diastereoselectivity and good yields. A reasonable mechanism for forming these 6,6-dibenzannulated spiroketals involving 6-endo-dig oxo-cyclization and 1,6-addition-cyclization cascades is proposed.",
author = "Shuai Liu and Lan, {Xin Chan} and Ke Chen and Hao, {Wen Juan} and Guigen Li and Tu, {Shu Jiang} and Bo Jiang",
note = "Funding Information: We are grateful for financial support from the NSFC (nos. 21232004, 21472071, and 21602087), PAPD of Jiangsu Higher Education Institutions, the Outstanding Youth Fund of JSNU (YQ2015003), NSF of Jiangsu Province (BK20151163 and BK20160212), the Qing Lan Project and NSF of Jiangsu Education Committee (15KJB150006). Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",
year = "2017",
month = jul,
day = "21",
doi = "10.1021/acs.orglett.7b01705",
language = "English",
volume = "19",
pages = "3831--3834",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society (ACS)",
number = "14",
}