Aerobic training increases expression levels of SIRT3 and PGC-1α in skeletal muscle of overweight adolescents without change in caloric intake

Katya Vargas-Ortiz, Victoriano Perez-Vazquez, Francisco J. Diaz-Cisneros, Arturo Figueroa, Lizbeth M. Jiménez-Flores, Gustavo Rodriguez-DelaRosa, Maciste H. Macias

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Sirtuin 3 enzyme (SIRT3) is involved in the regulation of mitochondrial energy homeostasis by activating Peroxisome proliferator-activated receptor-gamma coactivator (PGC-1α). Murine models have shown that the protein SIRT3 was modified by exercise and diet, however, the effect of exercise without diet in humans has not been examined. Propose of this paper was to analyze the effect of aerobic training on SIRT3 and PGC-1α in skeletal muscle of overweight adolescents without change in caloric intake. Fourteen overweight or obese male adolescents (15.5 ± 0.8 years) trained 3 days-week/50 min x session, at 70-80% of maximal heart rate for 12 weeks. Anthropometrics and skeletal muscle biopsies from the vastus lateralis were taken before and after the exercise program to measure adiposity, SIRT3, and PGC-1α proteins. Peak aerobic capacity (VO2peak) was estimated before and after training. The participants did not change their eating habits during the intervention. SIRT3 (1.05 ± 0.11 vs. 1.25 ± 0.14 AU, p = .014) and PGC-1a (1.06 ± 0.15 Vs 1.39 ± 0.20 AU, p = .009) increased. Fat percentage and waist circumference decreased (p < .05). VO2peak increased after training (p < .001). There was a significant association between SIRT3 and PGC-1α after training program. These data suggest that aerobic training increased SIRT3 and PGC-1a expression levels in sedentary, overweight, or obese adolescents.

Original languageEnglish
Pages (from-to)177-184
Number of pages8
JournalPediatric Exercise Science
Volume27
Issue number2
DOIs
StatePublished - May 1 2015

Keywords

  • Aerobic
  • Body composition
  • Health
  • Training

Fingerprint Dive into the research topics of 'Aerobic training increases expression levels of SIRT3 and PGC-1α in skeletal muscle of overweight adolescents without change in caloric intake'. Together they form a unique fingerprint.

  • Cite this

    Vargas-Ortiz, K., Perez-Vazquez, V., Diaz-Cisneros, F. J., Figueroa, A., Jiménez-Flores, L. M., Rodriguez-DelaRosa, G., & Macias, M. H. (2015). Aerobic training increases expression levels of SIRT3 and PGC-1α in skeletal muscle of overweight adolescents without change in caloric intake. Pediatric Exercise Science, 27(2), 177-184. https://doi.org/10.1123/pes.2014-0112