Advances in the role of minerals in immunobiology

Julian E. Spallholz, Janice R. Stewart

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Immunology and our understanding of its various cells, immunoglobulins and lymphokines are recent events that date from the work of Pasteur and Metchnikoff in the late nineteenth century. Experimental evidence has shown the importance of adequate dietary protein and vitamins. The present review examines past and recent experimental evidence for the role of minerals in the functioning of the immune system. Included is in vivo and in vitro information on the macrominerals; calcium and magnesium, the micro-(trace) minerals; iron, zinc, copper, and selenium as they affect various components of the immune system. The effects of gold as either goldthiomaleate or gold-thioglucose on selenium is also reviewed.

Original languageEnglish
Pages (from-to)129-151
Number of pages23
JournalBiological Trace Element Research
Issue number3
StatePublished - Mar 1989


  • Minerals and immunobiology
  • calcium, magnesium in immunology
  • copper and selenium in immunology
  • macrominerals and immunology
  • trace elements and immunology
  • zinc and iron in immunology


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