Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation.

Heejin Jun, Y Ma, Y Chen, J Gong, S Liu, J Wang, A J Knights, X Qiao, M P Emont, S Kajimura, J Wu, X. Z.Shawn Xu

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Jun et al. show that adipocyte-autonomous CHRNA2 signaling mediates adaptive thermogenesis after cold exposure and metabolic homeostasis during high fat diet feeding. Upon activation after acute calorie excess, CHRNA2 signaling regulates both UCP1- and creatine-mediated pathways. CHRNA2-glycolytic beige adipocytes axis regulates a β-adrenergic-independent signaling pathway.

Original languageEnglish
Pages (from-to)106-116.e5
JournalDevelopmental Cell
Issue number1
StatePublished - Jul 6 2020


  • beige fat
  • CHRNA2
  • diet-induced thermogenesis
  • g-beige fat


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