@article{2703247ba58245938ac6fba8fb21fbe0,
title = "Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation.",
abstract = "Jun et al. show that adipocyte-autonomous CHRNA2 signaling mediates adaptive thermogenesis after cold exposure and metabolic homeostasis during high fat diet feeding. Upon activation after acute calorie excess, CHRNA2 signaling regulates both UCP1- and creatine-mediated pathways. CHRNA2-glycolytic beige adipocytes axis regulates a β-adrenergic-independent signaling pathway.",
keywords = "beige fat, CHRNA2, diet-induced thermogenesis, g-beige fat",
author = "Heejin Jun and Y Ma and Y Chen and J Gong and S Liu and J Wang and Knights, {A J} and X Qiao and Emont, {M P} and S Kajimura and J Wu and Xu, {X. Z.Shawn}",
note = "Funding Information: This research was supported by grants from the National Institutes of Health (R01DK107583 to J. Wu), (R01DK97441 to S.K.), and (R35GM126917 to X.Z.S.X.) and the American Diabetes Association (1-18-IBS-281 to J. Wu), fellowships from the Chinese Scholarship Council (201806370290 to Y.M. 201908420207 to J. Wang, and 201606100214 to X.Q.), and a Michigan Life Sciences Fellowship to A.J.K. This work utilized the Molecular Genetics Core of the Michigan Diabetes Research Center funded by NIH grant no. P30-DK020572 from the NIDDK. H.J. Y.M. Y.C. J.G. S.L. J. Wang, A.J.K. X.Q. and M.P.E. performed experiments; H.J. Y.M. X.Z.S.X. S.K. and J. Wu analyzed data; H.J. Y.M. A.J.K. and J. Wu wrote the manuscript; J. Wu oversaw the study. The authors declare no competing interests. Funding Information: This research was supported by grants from the National Institutes of Health ( R01DK107583 to J. Wu), ( R01DK97441 to S.K.), and ( R35GM126917 to X.Z.S.X.) and the American Diabetes Association ( 1-18-IBS-281 to J. Wu), fellowships from the Chinese Scholarship Council ( 201806370290 to Y.M., 201908420207 to J. Wang, and 201606100214 to X.Q.), and a Michigan Life Sciences Fellowship to A.J.K. This work utilized the Molecular Genetics Core of the Michigan Diabetes Research Center funded by NIH grant no. P30-DK020572 from the NIDDK. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = jul,
day = "6",
doi = "10.1016/j.devcel.2020.05.017",
language = "English",
volume = "54",
pages = "106--116.e5",
journal = "Developmental Cell",
issn = "1534-5807",
number = "1",
}