TY - JOUR
T1 - Adipose tissue inflammation in insulin resistance
T2 - Review of mechanisms mediating anti-inflammatory effects of omega-3 polyunsaturated fatty acids
AU - Pahlavani, Mandana
AU - Ramalho, Theresa
AU - Koboziev, Iurii
AU - Lemieux, Monique J.
AU - Jayarathne, Shasika
AU - Ramalingam, Latha
AU - Filgueiras, Luciano R.
AU - Moustaid-Moussa, Naima
N1 - Funding Information:
funding This work was funded in part by the Presidential Cluster Hire Tier Obesity Research Cluster at Texas Tech University, SPRINT funds (TTU) FAPESP TTU to NMM and LRF, and CAPES (TR). NMM is supported in part by NIH/ NCCIH grant #R15AT00887901A1.
Publisher Copyright:
© 2017 American Federation for Medical Research (unless otherwise stated in the text of the article).
PY - 2017/10
Y1 - 2017/10
N2 - Obesity is an increasingly costly and widespread epidemic, effecting 1 in 10 adults worldwide. It has been causally linked with both the metabolic syndrome and insulin resistance, both of which are associated with increased chronic inflammation. The exact mechanisms through which inflammation may contribute to both MetS and IR are numerous and their details are still largely unknown. Recently, micro-RNAs (miRNAs) have emerged as potential interventional targets due to their potential preventive roles in the pathogenesis of several diseases, including MetS and obesity. The purpose of this review paper is to discuss some of the known roles of miRNAs as mediators of inflammation-associated obesity and IR and how omega-3 polyunsaturated fatty acids may be used as a nutritional intervention for these disorders.
AB - Obesity is an increasingly costly and widespread epidemic, effecting 1 in 10 adults worldwide. It has been causally linked with both the metabolic syndrome and insulin resistance, both of which are associated with increased chronic inflammation. The exact mechanisms through which inflammation may contribute to both MetS and IR are numerous and their details are still largely unknown. Recently, micro-RNAs (miRNAs) have emerged as potential interventional targets due to their potential preventive roles in the pathogenesis of several diseases, including MetS and obesity. The purpose of this review paper is to discuss some of the known roles of miRNAs as mediators of inflammation-associated obesity and IR and how omega-3 polyunsaturated fatty acids may be used as a nutritional intervention for these disorders.
KW - inflammation
KW - obesity
KW - polyunsaturated fatty acids
UR - http://www.scopus.com/inward/record.url?scp=85030770555&partnerID=8YFLogxK
U2 - 10.1136/jim-2017-000535
DO - 10.1136/jim-2017-000535
M3 - Review article
C2 - 28954844
AN - SCOPUS:85030770555
VL - 65
SP - 1021
EP - 1027
JO - Journal of Investigative Medicine
JF - Journal of Investigative Medicine
SN - 1081-5589
IS - 7
ER -