TY - JOUR
T1 - Adhesive, Self-Healing, and Antibacterial Chitosan Hydrogels with Tunable Two-Layer Structures
AU - Wang, Yinggui
AU - Garcia, Celine R.
AU - Ding, Zhenya
AU - Gabrilska, Rebecca
AU - Rumbaugh, Kendra P.
AU - Wu, Jiangyu
AU - Liu, Qingye
AU - Li, Wei
N1 - Funding Information:
W.L. acknowledges funding support from New Faculty Startup Funds from Texas Tech University. K.P.R. acknowledges funding support from the National Institutes of Health (R21 AI137462-01A1) and the Ted Nash Long Life Foundation. Q.L. acknowledges the financial support from the Natural Science Foundation of China (No. 51603195). Dedicated to the memory of Professor Lina Zhang.
Publisher Copyright:
© 2020 American Chemical Society.
PY - 2020/12/14
Y1 - 2020/12/14
N2 - Hydrogels with multifunctional properties such as biocompatibility, adhesion, and self-healing and inherent antibacterial properties are of great significance in biomedical applications, especially for wound dressings and drug release. However, it remains a significant challenge to combine all of these properties in a one-component hydrogel system. Furthermore, most injectable hydrogels are mechanically weak and not self-healing, which limits their applications as wound dressings. Herein, we designed a hydrogel with a tunable two-layer structure that endows the hydrogel with adhesion, self-healing, and antibacterial properties in different layers. First, chitosan (CHI) was oxidized to aldehyde-chitosan (ACHI). The Schiff base reaction was then used to fabricate the CHI/ACHI hydrogel resulting in the first layer. For the second layer, a physical cross-linking process using phytic acid (PA) as a sequential cross-linker was achieved, resulting in a CHI/ACHI/PA hydrogel. The CHI/ACHI hydrogel exhibited good injectable, adhesion, and self-healing properties. After cross-linking with PA, the CHI/ACHI/PA hydrogel showed enhanced mechanical properties, which enabled it to act as a protective layer. Additionally, the antibacterial test and cytotoxicity tests performed on this two-layer structured CHI/ACHI hydrogel exhibited excellent inherent antibacterial activity and good biocompatibility. The biocompatible injectable hydrogel was endowed with more possibilities relying on its self-healing and antibacterial abilities. These properties endorse the CHI/ACHI two-layer hydrogel as an excellent candidate for biological applications, especially wound dressings.
AB - Hydrogels with multifunctional properties such as biocompatibility, adhesion, and self-healing and inherent antibacterial properties are of great significance in biomedical applications, especially for wound dressings and drug release. However, it remains a significant challenge to combine all of these properties in a one-component hydrogel system. Furthermore, most injectable hydrogels are mechanically weak and not self-healing, which limits their applications as wound dressings. Herein, we designed a hydrogel with a tunable two-layer structure that endows the hydrogel with adhesion, self-healing, and antibacterial properties in different layers. First, chitosan (CHI) was oxidized to aldehyde-chitosan (ACHI). The Schiff base reaction was then used to fabricate the CHI/ACHI hydrogel resulting in the first layer. For the second layer, a physical cross-linking process using phytic acid (PA) as a sequential cross-linker was achieved, resulting in a CHI/ACHI/PA hydrogel. The CHI/ACHI hydrogel exhibited good injectable, adhesion, and self-healing properties. After cross-linking with PA, the CHI/ACHI/PA hydrogel showed enhanced mechanical properties, which enabled it to act as a protective layer. Additionally, the antibacterial test and cytotoxicity tests performed on this two-layer structured CHI/ACHI hydrogel exhibited excellent inherent antibacterial activity and good biocompatibility. The biocompatible injectable hydrogel was endowed with more possibilities relying on its self-healing and antibacterial abilities. These properties endorse the CHI/ACHI two-layer hydrogel as an excellent candidate for biological applications, especially wound dressings.
KW - adhesion
KW - antibacterial
KW - injectable hydrogels
KW - self-healing
KW - two-layer structure
UR - http://www.scopus.com/inward/record.url?scp=85097754550&partnerID=8YFLogxK
U2 - 10.1021/acssuschemeng.0c05730
DO - 10.1021/acssuschemeng.0c05730
M3 - Article
AN - SCOPUS:85097754550
VL - 8
SP - 18006
EP - 18014
JO - ACS Sustainable Chemistry and Engineering
JF - ACS Sustainable Chemistry and Engineering
SN - 2168-0485
IS - 49
ER -