Adenovirus 36 infection and daycare starting age are associated with adiposity in children and adolescents

Ana Carolina Lobor Cancelier, Nikhil V. Dhurandhar, Swetha Peddibhotla, Richard L. Atkinson, Helena C.G. Silva, Daisson J. Trevisol, Fabiana Schuelter-Trevisol

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: This study aimed to investigate human adenovirus 36 (Adv36) as an associated factor for adiposity in children and adolescents aged 9–12 years. Methods: This was a case-control study comparing overweight (cases) and eutrophic (controls) children and adolescents aged 9–12 years based on their body mass index in relation to human adenovirus 36 serology. Human adenovirus 36-specific neutralizing antibodies were assessed using the serum neutralization assay, and a questionnaire regarding the subjects’ personal backgrounds, breastfeed history, age of starting daycare, and eating and exercise habits was also applied. Results: A total of 101 (51, eutrophic; 50, overweight) children were included in the study. The Adv36 seropositivity rate was of 15.8%, which increased the chance of being overweight by 3.17 times (p = 0.049). Enrollment in a full-time daycare center before the age of 24 months increased the chance of being overweight by 2.78 times (p = 0.027). Metabolic parameters (total cholesterol and blood glucose) were insignificantly different among children who were seropositive or seronegative for human adenovirus 36. Conclusion: This study concluded that excessive weight was positively associated with seropositivity for human adenovirus 36. Early enrollment in a full-time daycare was also an associated factor for obesity. Such data, confirmed in new studies, reinforces the role of human adenovirus 36 in the increase of childhood adiposity.

Original languageEnglish
Pages (from-to)420-425
Number of pages6
JournalJornal de Pediatria
Volume97
Issue number4
DOIs
StatePublished - Jul 1 2021

Keywords

  • Antibody
  • Human adenovirus
  • Infectobesity
  • Pediatric obesity
  • Risk factors

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