TY - JOUR
T1 - Adenovirus 36 infection and daycare starting age are associated with adiposity in children and adolescents
AU - Cancelier, Ana Carolina Lobor
AU - Dhurandhar, Nikhil
AU - Peddibhotla, Swetha
AU - Atkinson, Richard L.
AU - Silva, Helena C.G.
AU - Trevisol, Daisson J.
AU - Schuelter-Trevisol, Fabiana
N1 - Publisher Copyright:
© 2020 Sociedade Brasileira de Pediatria
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - Objective: This study aimed to investigate human adenovirus 36 (Adv36) as an associated factor for adiposity in children and adolescents aged 9–12 years. Methods: This was a case-control study comparing overweight (cases) and eutrophic (controls) children and adolescents aged 9–12 years based on their body mass index in relation to Adv36 serology. Adv36-specific neutralizing antibodies were assessed using the serum neutralization assay, and a questionnaire regarding the subjects’ personal backgrounds, breastfeed history, age of starting daycare, and eating and exercise habits was also applied. Results: A total of 101 (51, eutrophic; 50, overweight) children were included in the study. The Adv36 seropositivity rate was of 15.8%, which increased the chance of being overweight by 3.17 times (p = 0.049). Enrollment in a full-time daycare center before the age of 24 months increased the chance of being overweight by 2.78 times (p = 0.027). Metabolic parameters (total cholesterol and blood glucose) were insignificantly different among children who were seropositive or seronegative for Adv36. Conclusion: This study concluded that excessive weight was positively associated with seropositivity for Adv36. Early enrollment in a full-time daycare was also an associated factor for obesity. Such data, confirmed in new studies, reinforces the role of Adv36 in the increase of childhood adiposity.
AB - Objective: This study aimed to investigate human adenovirus 36 (Adv36) as an associated factor for adiposity in children and adolescents aged 9–12 years. Methods: This was a case-control study comparing overweight (cases) and eutrophic (controls) children and adolescents aged 9–12 years based on their body mass index in relation to Adv36 serology. Adv36-specific neutralizing antibodies were assessed using the serum neutralization assay, and a questionnaire regarding the subjects’ personal backgrounds, breastfeed history, age of starting daycare, and eating and exercise habits was also applied. Results: A total of 101 (51, eutrophic; 50, overweight) children were included in the study. The Adv36 seropositivity rate was of 15.8%, which increased the chance of being overweight by 3.17 times (p = 0.049). Enrollment in a full-time daycare center before the age of 24 months increased the chance of being overweight by 2.78 times (p = 0.027). Metabolic parameters (total cholesterol and blood glucose) were insignificantly different among children who were seropositive or seronegative for Adv36. Conclusion: This study concluded that excessive weight was positively associated with seropositivity for Adv36. Early enrollment in a full-time daycare was also an associated factor for obesity. Such data, confirmed in new studies, reinforces the role of Adv36 in the increase of childhood adiposity.
KW - Antibody
KW - Human adenovirus
KW - Infectobesity
KW - Pediatric obesity
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=85090548533&partnerID=8YFLogxK
U2 - 10.1016/j.jped.2020.08.002
DO - 10.1016/j.jped.2020.08.002
M3 - Article
AN - SCOPUS:85090548533
JO - Jornal de Pediatria
JF - Jornal de Pediatria
SN - 0021-7557
ER -