TY - JOUR
T1 - Acute toxicity of 2,4,6-trinitrotoluene, 2,4-dinitrotoluene, and 2,6-dinitrotoluene in the adult bullfrog (Lithobates catesbeiana)
AU - Paden, Norka E.
AU - Smith, Ernest E.
AU - Kendall, Ronald J.
PY - 2008/6
Y1 - 2008/6
N2 - 2,4,6-Trinitrotoluene (TNT) is one of the most prevalent high explosives in the environment. 2,4-Dinitrotoluene (2,4-DNT) and 2,6-dinitrotoluene (2,6-DNT) are the most common isoforms of dinitrotoluene. The goal of this study was to determine the acute toxic effects of TNT, 2,4-DNT, and 2,6-DNT in adult male bullfrogs. The LD 50 for TNT was 1,060 mg/kg BW while the LD 50 for 2,4-DNT and 2,6-DNT was 1,098 mg/kg BW. All three compounds elicited similar symptoms of toxicity including changes of skin color, body weight, development of seizures, liver and kidney necrosis, and lung cyanosis. Relative organ weights did not show significant change.
AB - 2,4,6-Trinitrotoluene (TNT) is one of the most prevalent high explosives in the environment. 2,4-Dinitrotoluene (2,4-DNT) and 2,6-dinitrotoluene (2,6-DNT) are the most common isoforms of dinitrotoluene. The goal of this study was to determine the acute toxic effects of TNT, 2,4-DNT, and 2,6-DNT in adult male bullfrogs. The LD 50 for TNT was 1,060 mg/kg BW while the LD 50 for 2,4-DNT and 2,6-DNT was 1,098 mg/kg BW. All three compounds elicited similar symptoms of toxicity including changes of skin color, body weight, development of seizures, liver and kidney necrosis, and lung cyanosis. Relative organ weights did not show significant change.
KW - Bullfrog
KW - High explosives
KW - LD
KW - Up-and-Down procedure
UR - http://www.scopus.com/inward/record.url?scp=46249124279&partnerID=8YFLogxK
U2 - 10.1007/s00128-008-9467-9
DO - 10.1007/s00128-008-9467-9
M3 - Article
C2 - 18551238
AN - SCOPUS:46249124279
SN - 0007-4861
VL - 80
SP - 487
EP - 491
JO - Bulletin of Environmental Contamination and Toxicology
JF - Bulletin of Environmental Contamination and Toxicology
IS - 6
ER -