Acute toxicity of 2,4,6-trinitrotoluene, 2,4-dinitrotoluene, and 2,6-dinitrotoluene in the adult bullfrog (Lithobates catesbeiana)

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Abstract

2,4,6-Trinitrotoluene (TNT) is one of the most prevalent high explosives in the environment. 2,4-Dinitrotoluene (2,4-DNT) and 2,6-dinitrotoluene (2,6-DNT) are the most common isoforms of dinitrotoluene. The goal of this study was to determine the acute toxic effects of TNT, 2,4-DNT, and 2,6-DNT in adult male bullfrogs. The LD 50 for TNT was 1,060 mg/kg BW while the LD 50 for 2,4-DNT and 2,6-DNT was 1,098 mg/kg BW. All three compounds elicited similar symptoms of toxicity including changes of skin color, body weight, development of seizures, liver and kidney necrosis, and lung cyanosis. Relative organ weights did not show significant change.

Original languageEnglish
Pages (from-to)487-491
Number of pages5
JournalBulletin of Environmental Contamination and Toxicology
Volume80
Issue number6
DOIs
StatePublished - Jun 2008

Keywords

  • Bullfrog
  • High explosives
  • LD
  • Up-and-Down procedure

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